Evidence map›Paper›PMID 40295125›Full record

ArticleBMJ open2025

Predicting Outcomes using DIGital TechnologY in patients with Interstitial Lung Disease (PRODIGY-ILD): Protocol for a Prospective Cohort Study.

Emer Gunne, Sinead Holden, Alessandro N Franciosi, Michael Keane, Cormac McCarthy, Peter Doran

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emer GunneSchool of Medicine, University College Dublin, Dublin, Ireland emer.gunne@ucdconnect.ie.ORCID http://orcid.org/0000-0002-6939-1586
Sinead HoldenUniversity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-7314-2152
Alessandro N FranciosiRespiratory Medicine, St. Vincent's University Hospital, Dublin, Ireland.
Michael KeaneUniversity College Dublin, Dublin, Ireland.
Cormac McCarthySchool of Medicine, University College Dublin, Dublin, Ireland.
Peter DoranSchool of Medicine, University College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInterstitial lung disease (ILD) patients may develop a progressive phenotype usually characterised by progressive pulmonary fibrosis. While this condition is life-limiting, wide variations in its clinical course have made it difficult to predict the rate of disease progression, onset of acute exacerbations and mortality. New approaches are needed to predict the clinical course of ILD, to enable treatment planning, evaluation and clinical trial design. Advances in digital health technologies have facilitated the ability to collect 'real-time' data to monitor diseases. These data, including physiological measures, activity indices and patient-reported outcomes, may be useful as components of new outcome predictors. The objective of this study is to first deploy comprehensive data collection enabling deep profiling of patients with ILD and to use these data to develop better predictors of outcome. Finally, these predictions will be evaluated based on real observed outcomes for individual patients. METHODS AND ANALYSIS: This study is a prospective cohort study with 50 participants. INCLUSION CRITERIA: Age 18 years or older with a diagnosis of ILD and the ability to provide written informed consent. EXCLUSION CRITERIA: Age under 18 years or unwilling to wear a smartwatch for the duration of the study. Participants will be provided with a smartwatch to passively collect biometric data. These data will be combined with clinical history and course, in addition to a set of patient-reported outcome measures. Participants will be followed for 3 years to assess the rate of disease progression, occurrence of acute exacerbations and mortality. Initial data will be used to develop clinical prediction models. These models will be further evaluated for accuracy using regular follow-up data. ETHICS AND DISSEMINATION: This study was approved by the St. Vincent's University Hospital Research Ethics Committee, Dublin, Ireland (reference no: RS23-023). Results will be presented at medical conferences and disseminated via peer-reviewed journals.

Indexed as

Digital TechnologyLung Diseases, InterstitialDisease ProgressionHumansMalePatient Reported Outcome MeasuresPrognosisProspective StudiesResearch DesignDigital TechnologyInterstitial lung diseaseMachine LearningObservational StudyPatient Reported Outcome MeasuresWearable Electronic Devices

Identifiers

PMID40295125
PMCPMC12039023

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.