ArticleIn vivo (Athens, Greece)
Effect of DNA Aptamer Concentration on the Stability of PDA Nanoparticle-based Electrochemical Biosensor to Detect Glycated Albumin.
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Abstract
BACKGROUND/
aimThe glycated albumin (GA), a potential biomarker for monitoring diabetes mellitus, reflects short-term glycemia and is not influenced by conditions that falsely alter hemoglobin A1c (HbA1c) levels. This study presents a comprehensive evaluation of DNA aptamer-functionalized polydopamine nanoparticles (PDA NPs) for developing a stable biosensor targeting GA. MATERIALS AND
methodsDNA aptamers, conjugated to PDA NPs at varying aptamer concentrations (0.05, 0.5, and 5 μM), were systematically analyzed to understand their impact on the morphological, electrochemical behavior, and stable responses of the biosensor.
resultsMorphological assessments using transmission electron microscopy, scanning electron microscopy, and atomic force microscopy confirmed the stability of PDA NPs after conjugation with aptamers. Electrochemical characterization demonstrated enhanced electron transfer efficiency at an optimal aptamer concentration (0.5 μM) for GA detection while stability testing over 30 days indicated sustained sensor functionality.
conclusionThe PDA-0.5 μM aptamer conjugations balance structural integrity, and stability, emphasizing the importance of aptamer concentration optimization for practical biosensor applications.
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