Evidence map›Paper›PMID 40295009›Full record

ArticleIn vivo (Athens, Greece)

Pathogenic Variants and Allele Loss of the NF2 and LZTR1 Gene in Sporadic Vestibular Schwannoma.

Maria Breun, Tim Schulz, Camelia M Monoranu, Ralf-Ingo Ernestus, Cordula Matthies, Mario Löhr, Lan Kluwe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria BreunDepartment of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany; breun_m@ukw.de.
Tim SchulzDepartment of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany.
Camelia M MonoranuDepartment of Neuropathology, Institute of Pathology, University Hospital of Würzburg, Würzburg, Germany.
Ralf-Ingo ErnestusDepartment of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany.
Cordula MatthiesDepartment of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany.
Mario LöhrDepartment of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany.
Lan KluweDepartment of Neurology, University Hospital Hamburg-Eppendorf, Hamburg-Eppendorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimPathogenic variants and allele-loss of the PATIENTS AND

methodsForty-one sporadic vestibular schwannomas from 26 male and 15 female patients were included. DNA from tumor tissues was sequenced with a custom panel for the

resultsAmong the 41 tumor samples, 34 had one pathogenic variant or an allele-loss of

conclusionThere was no correlation between phenotype and genetic alterations of the

Indexed as

AllelesGenetic Predisposition to DiseaseLoss of HeterozygosityNeurofibromin 2Neuroma, AcousticTranscription FactorsAdultAgedFemaleGene FrequencyHumansMaleMiddle AgedLZTR1 protein, humanNeurofibromin 2NF2 protein, humanTranscription Factorsgenotypenext generation sequencing (NGS)pathogenic variantsphenotypeSporadic vestibular schwannoma

Identifiers

PMID40295009
PMCPMC12042009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.