Evidence map›Paper›PMID 40294936›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[High expression of CDKN3 promotes migration and invasion of gastric cancer cells by regulating the p53/NF-κB signaling pathway and inhibiting cell apoptosis].

Yi Zhang, Yu Shen, Zhiqiang Wan, Song Tao, Yakui Liu, Shuanhu Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yi ZhangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.
Yu ShenDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.
Zhiqiang WanDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.
Song TaoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.
Yakui LiuDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.
Shuanhu WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of CDKN3 in gastric cancer and its impact on prognosis of gastric cancer patients.

methodsWe analyzed CDKN3 expression in clinical specimens from 114 gastric cancer patients and assessed its association with 5-year postoperative survival of the patients. GO and KEGG enrichment analyses were used to predict the biological function and possible mechanism of CDKN3. The effects of lentivirus-mediated CDKN3 knockdown on biological behaviors of gastric cancer cells were evaluated using Transwell assay, CCK-8 assay, TUNEL staining, flow cytometry, and Western blotting.

resultsCDKN3 expression was significantly higher in gastric cancer tissues than in the adjacent tissues with significant correlations with CEA level, CA19-9 level, and T and N staging (

conclusionsCDKN3 is highly expressed in gastric cancer tissues and affects patient prognosis. CDKN3 overexpression promotes proliferation, invasion and migration and suppressed apoptosis of gastric cancer cells possibly through the p53/NF-κB signaling pathway.

Indexed as

ApoptosisCyclin-Dependent Kinase Inhibitor ProteinsNF-kappa BStomach NeoplasmsTumor Suppressor Protein p53Cell Line, TumorCell MovementCell ProliferationDual-Specificity PhosphatasesFemaleHumansMaleNeoplasm InvasivenessPrognosisSignal TransductionCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor ProteinsDual-Specificity PhosphatasesNF-kappa BTumor Suppressor Protein p53apoptosisCDKN3gastric cancerp53/NF-κBprognosisproliferation

Identifiers

PMID40294936
PMCPMC12037297

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