Evidence map›Paper›PMID 40294925›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].

Shuting Guo, Fuyang Cao, Yongxin Guo, Yanxiang Li, Xinyu Hao, Zhuoning Zhang, Zhikang Zhou, Li Tong, Jiangbei Cao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shuting GuoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Fuyang CaoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Yongxin GuoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Yanxiang LiDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Xinyu HaoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Zhuoning ZhangDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Zhikang ZhouDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Li TongDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Jiangbei CaoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Funding

National Natural Science Foundation of China 82271213
6 · The paper itself

Abstract

objectivesTo investigate the regulatory role of astrocytes in the dorsomedial hypothalamus (DMH) during sevoflurane anesthesia emergence.

methodsForty-two male C57BL/6 mice were randomized into 6 groups (

resultsAstrocyte activity in the DMH decreased progressively as sevoflurane concentration increased. During 2.0% sevoflurane anesthesia, the mice injected with the ChR2-expressing virus exhibited a significantly shortened wake-up time (

conclusionsOptogenetic activation of DMH astrocytes facilitates sevoflurane anesthesia emergence but does not significantly influence anesthesia induction. These findings offer new insights into the mechanisms underlying anesthesia emergence and may provide a potential target for accelerating postoperative recovery and managing anesthesia-related complications.

Indexed as

Anesthesia Recovery PeriodAstrocytesHypothalamusMethyl EthersAnesthetics, InhalationAnimalsElectroencephalographyMaleMiceMice, Inbred C57BLSevofluraneAnesthetics, InhalationMethyl EthersSevofluraneanesthesia emergenceastrocytesdmh regionsevoflurane

Identifiers

PMID40294925
PMCPMC12037299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.