Evidence map›Paper›PMID 40294848›Full record

ArticleThe journal of allergy and clinical immunology. In practice2025

Symptoms of Asthma Extracted Through Natural Language Processing and Their Associations With Acute Asthma Exacerbation in Adults With Mild Asthma.

Wansu Chen, Eric J Puttock, Fagen Xie, William Crawford, Michael Schatz, William M Vollmer, Stanley Xu, Robert S Zeiger

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Asthma Burden in Mild Adult Asthma in the PEARL Survey: Asthma Control and Health Status.The journal of allergy and clinical immunology. In practice · 2026
    Article
  2. Review
  3. Multimodal EHR-Based Prediction of Pediatric Asthma Exacerbations.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wansu ChenDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif. Electronic address: Wansu.Chen@KP.org.
Eric J PuttockDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.
Fagen XieDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.
William CrawfordDepartment of Allergy, Kaiser Permanente Southern California, Harbor City, Calif.
Michael SchatzDepartment of Allergy, Kaiser Permanente Southern California, San Diego, Calif.
William M VollmerKaiser Permanente Center for Health Research, Portland, Ore.
Stanley XuDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.
Robert S ZeigerDepartment of Allergy, Kaiser Permanente Southern California, San Diego, Calif; Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif.

Funding

Predicting Exacerbations of Asthma in Real-World Patients with Low Medical Utilization (PEARL)R01HL163049 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI Wansu Chen · 2023 to 2026
$3.0M
NHLBI NIH HHS R01 HL163049
6 · The paper itself

Abstract

backgroundIndividuals with mild asthma account for 30% to 40% of asthma exacerbations requiring emergency consultation, and nearly 30% had not-well controlled or poorly controlled asthma symptoms over the previous 4 weeks.

objectiveWe sought to estimate the prevalence of various asthma symptoms and assess their association with future acute asthma exacerbations (AAEs) in patients with mild asthma.

methodsThis was a retrospective cohort study. Using administrative data, we identified 198,873 adults aged 18 to 85 years, who met criteria for mild asthma between 2013 and 2018. The presence of cough, wheezing, dyspnea, and chest tightness in the 12 months before the index visit (t

resultsThe prevalence of cough, wheezing, dyspnea, and chest tightness was 67.0%, 47.7%, 41.3%, and 13.2%, respectively. Moreover, 6.5% of patients experienced an AAE in the 12 months after t

conclusionPatients with mild asthma who exhibit symptoms of dyspnea and wheezing (especially on multiple occasions) are at an increased risk for future AAEs and may benefit from therapeutic intervention and/or trigger-avoidance education.

Indexed as

AsthmaNatural Language ProcessingAdolescentAdultAgedAged, 80 and overCoughDisease ProgressionDyspneaFemaleHumansMaleMiddle AgedPrevalenceRespiratory SoundsRetrospective StudiesAcute asthma exacerbationAsthma burdenAsthma symptomsChest tightnessCoughDyspneaElectronic health recordsHealth care resource useLow utilizerMild asthmaWheezing

Identifiers

PMID40294848
PMCPMC12240703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.