Evidence map›Paper›PMID 40294460›Full record

ArticleBiochemical and biophysical research communications2025

Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice.

Reagan Strand, David J Orlicky, Ying Chen

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reagan StrandDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.
David J OrlickyDepartment of Pathology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CT, 80045, USA.
Ying ChenDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA. Electronic address: ying.chen@yale.edu.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Redox Regulation of O-GlcNAcylation Signaling in the Pathogenesis of Alcoholic Fatty Liver DiseaseR01AA028859 · NIAAA · YALE UNIVERSITY · PI Ying Chen · 2022 to 2026
$1.9M
NIAAA NIH HHS R01 AA028859NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Glutathione (GSH) and ascorbate (vitamin C) are key antioxidants with well-established biochemical and clinical interplay in protecting against oxidative stress. Glutamate-cysteine ligase is the rate-limiting enzyme in GSH biosynthesis; its modifier subunit (GCLM) regulates tissue GSH levels. L-gulono-γ-lactone oxidase (GULO) catalyzes a critical step in ascorbate biosynthesis; Gulo-knockout (Gulo

Indexed as

Ascorbic AcidAscorbic Acid DeficiencyGene DosageGlutamate-Cysteine LigaseGlutathioneScurvyAnimalsL-Gulonolactone OxidaseMaleMiceMice, Inbred C57BLMice, KnockoutOxidation-ReductionAscorbic AcidGCLM protein, mouseGlutamate-Cysteine LigaseGlutathioneL-Gulonolactone Oxidase

Identifiers

PMID40294460
PMCPMC12058385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.