Evidence map›Paper›PMID 40294260›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Radiation protection and structural stability of fungal melanin polylactic acid biocomposites in low Earth orbit.

Radames J B Cordero, Kim K de Groh, Quigly Dragotakes, Saranshu Singla, Christopher Maurer, Andrew Trunek, Arlene Chiu, Jonghyun Hwang, Sylvie Crowell, Theresa Benyo and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Radames J B CorderoDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.ORCID 0000-0002-3026-7094
Kim K de GrohNational Aeronautics and Space Administration Glenn Research Center, Cleveland, OH 44135.
Quigly DragotakesDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Saranshu SinglaDepartment of Polymer Science, School of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH 44325.ORCID 0000-0002-0690-3740
Christopher Maurerredhouse studio, Cleveland, OH 44113.
Andrew TrunekNational Aeronautics and Space Administration Glenn Research Center, Cleveland, OH 44135.
Arlene ChiuDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218.
Jonghyun HwangDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-6575-0940
Sylvie CrowellNational Aeronautics and Space Administration Glenn Research Center, Cleveland, OH 44135.
Theresa BenyoNational Aeronautics and Space Administration Glenn Research Center, Cleveland, OH 44135.
Susanna M ThonDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218.
Lynn J RothschildSpace Science and Astrobiology Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, CA 94035.
Ali DhinojwalaDepartment of Polymer Science, School of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH 44325.ORCID 0000-0002-3935-7467
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.ORCID 0000-0002-9402-9167

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
The biology of Cryptococcus neoformans melanizationR01AI171093 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall, JOSHUA D NOSANCHUK · 2023 to 2026
$3.2M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI171093-02NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI152078NIAID NIH HHS R01 AI171093
6 · The paper itself

Abstract

Materials in low Earth orbit (LEO) face radiation, atomic oxygen erosion, and extreme temperature fluctuations, which can severely compromise their structural and functional integrity. Developing lightweight, multifunctional materials capable of withstanding these harsh conditions is critical for long-term space exploration and sustainable extraterrestrial settlements. This study evaluates the structural stability and radiation shielding efficacy of polylactic acid (PLA) and biocomposites, including PLA infused with fungal melanin, synthetic melanin, or animal melanin, and a compressed mycelium (CMy) coated with PLA (PLA-CMy), after exposure to the LEO environment. Samples were deployed on the Materials International Space Station Experiment-Flight Facility platform for approximately 6 mo in zenith- and wake-facing orientations. Postflight analyses comparing flight-exposed samples to Earth controls revealed composition- and orientation-dependent differences in mass loss, optical properties, and surface morphology. Notably, fungal melanin reduced mass loss and surface wrinkle formation, indicating a protective effect against PLA degradation in LEO. Biocomposites also demonstrated shielding effects by protecting an underlying polyvinyl chloride backing layer from damage. These findings demonstrate PLA's performance in space and highlight fungal melanin as a bioderived additive to enhance PLA resilience under LEO conditions, advancing the development of sustainable materials for future space missions.

Indexed as

Biocompatible MaterialsMelaninsPolyestersRadiation ProtectionRadiation-Protective AgentsEarth, PlanetSpace FlightBiocompatible MaterialsMelaninsPolyesterspoly(lactide)Radiation-Protective Agentsfungimelaninradiationspace

Identifiers

PMID40294260
PMCPMC12067201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.