Observational studyEchocardiography (Mount Kisco, N.Y.)2025
Predictors of Incident Heart Failure in Patients With Chronic Chagas Disease Cardiomyopathy.
Observational study in Echocardiography (Mount Kisco, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Vaccines against chronicExpert review of vaccines · 2026Review
- Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Chagas-specific Death and Competing Risk of Mortality in Chile: A Nationwide Retrospective Cohort Study, 2007-2021.Open forum infectious diseases · 2026Article
- Cardiac imaging in Chagas cardiomyopathy for phenotypic characterisation and risk stratification.Heart failure reviews · 2026Review
- Acute Heart Failure Due to Chagas Disease: Still a Challenge in the 21st Century.Arquivos brasileiros de cardiologia · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposePatients with chronic Chagas cardiomyopathy (CCC) have a high mortality due to heart failure (HF). The aim of this study was to investigate clinical and echocardiographic predictors of incident HF in patients with CCC.
methodsSingle-center retrospective longitudinal observational study which included 176 adult patients (59.1% women; 53.9 ± 10 years old; mean left ventricular [LV] ejection fraction 62% ± 10%) at an early stage of CCC (electrocardiogram and/or wall motion changes but no HF). The primary outcome was incident HF. The association between studied parameters with incident HF was performed by competing-risk survival regression models using the Fine and Gray method.
resultsAfter a mean follow-up of 8.8 ± 3.6 years, 42 patients progressed to HF (27.04 cases/1000 patient-years). A model 0 adjusted for clinical and 2D-Doppler echocardiographic parameters and for all-cause mortality revealed diabetes mellitus (HR 4.91, 95% CI 1.67-14.4, p = 0.004), LV ejection fraction (HR 0.96, 95% CI 0.93-0.99, p = 0.022), and E' velocity (HR 0.79, 95% CI 0.67-0.95, p = 0.01) as independently associated with incident HF. The addition of strain-derived parameters to model 0 revealed that LV global circumferential strain (HR 0.83, 95% CI 0.78-0.89, p < 0.001) and left atrial booster contraction strain (HR 1.14, 95% CI 1.02-1.28, p = 0.022) were associated with incident HF.
conclusionWhile most clinical parameters were not associated with incident HF in patients with CCC, echocardiographic parameters, including LV systolic and diastolic function and strain-derived parameters, were associated with incident HF in patients with CCC. This knowledge can be very useful for planning the care and follow-up of these patients.
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