Evidence map›Paper›PMID 40294090›Full record

ArticleMagnetic resonance in medicine2025

Comparison of twelve-layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI.

Patrik Jan Gallinnis, Rika Möller, Alexandra Ljimani, Yusuf Cabuk, Marie Scheuer, Charlotte Böttger, Cecilia Liang, Armin M Nagel, Eric Bechler, Hans-Jörg Wittsack and 2 more

Abstract readComparative Study
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrik Jan GallinnisDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Rika MöllerDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Alexandra LjimaniDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID https://orcid.org/0000-0002-9748-9927
Yusuf CabukDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Marie ScheuerDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Charlotte BöttgerDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Cecilia LiangDiagnostic and Interventional Radiology, Department of Radiology, University Hospital of Tuebingen, Tübingen, Germany.
Armin M NagelInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID https://orcid.org/0000-0003-0948-1421
Eric BechlerDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID https://orcid.org/0000-0001-8864-4879
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID https://orcid.org/0000-0002-5830-423X
Anja Müller-LutzDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Benedikt KampDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Funding

Jürgen Manchot Stiftung, PJG and RK
6 · The paper itself

Abstract

purpose

methodsTen healthy volunteers were examined on a 3 T MRI-system.

resultsThe evaluated CMSG by the two methods does not differ statistically significantly. Compared to the Line method, the TLCO method provides improved results in terms of reliability, precision, reproducibility, and concordance in intra- and inter-reader analyses. A CMSG of (6.7 ± 2.6) mM/mm was determined using the TLCO method in the segmentation process with the lowest standard deviation.

conclusionThe TLCO method shows superior performance in determining the CMSG compared to the Line method. Accordingly, the use of the TLCO method is recommended for future renal CMSG studies.

Indexed as

Image Processing, Computer-AssistedKidneyMagnetic Resonance ImagingSodiumAdultAlgorithmsFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMaleReproducibility of ResultsSodium IsotopesYoung AdultSodiumSodium Isotopescorticomedullary 23Na gradientkidney sodium MRIsodium MRI23Na MR imagingtwelve‐layer concentric objects (TLCO) method

Identifiers

PMID40294090
PMCPMC12202721

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.