Evidence map›Paper›PMID 40293964›Full record

ReviewPLoS pathogens2025

Tailoring mRNA lipid nanoparticles for antifungal vaccines.

Yeqi Li, Richard B Meagher, Xiaorong Lin

Abstract readReview
In one paragraph

Review in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yeqi LiDepartment of Microbiology, University of Georgia, Athens, GeorgiaUnited States of America.
Richard B MeagherDepartment of Genetics, University of Georgia, Athens, GeorgiaUnited States of America.
Xiaorong LinDepartment of Microbiology, University of Georgia, Athens, GeorgiaUnited States of America.ORCID 0000-0002-3390-8387

Funding

Defining the genetic network governing cryptococcal morphological transitionR01AI140719 · NIAID · UNIVERSITY OF GEORGIA · PI Xiaorong Lin · 2018 to 2026
$4.1M
Develop and Assess mRNA Lipid Nanoparticle Vaccines Against CryptococcosisR21AI170106 · NIAID · UNIVERSITY OF GEORGIA · PI LIN, XIAORONG, MEAGHER, RICHARD BRIAN · 2023 to 2024
$384k
NIAID NIH HHS R01 AI140719NIAID NIH HHS R21 AI170106
6 · The paper itself

Abstract

Vaccination is one of the most effective public health measures for preventing and managing infectious diseases. Despite intensive efforts from the relatively small medical mycology community, developing effective vaccines against invasive fungal infections remains a scientific challenge. This is predominantly due to large antigenic repertoires, complicated life cycles, and the capacity of fungal pathogens to evade the host immune system. Additionally, antifungal vaccines often need to work for at-risk individuals who are immunodeficient. We anticipate that the success of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its exploration for various infectious diseases and cancers will usher a new wave of antifungal vaccine research. Herein, we discuss recent advancements and key scientific areas that need to be explored to actualize the development of effective antifungal mRNA vaccines.

Indexed as

Fungal VaccinesLipidsMycosesNanoparticlesRNA, MessengerAnimalsCOVID-19HumansLiposomesSARS-CoV-2Fungal VaccinesLipid NanoparticlesLipidsLiposomesRNA, Messenger

Identifiers

PMID40293964
PMCPMC12036839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.