SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Effect of Excessive Daytime Sleepiness and Long Sleep Duration on All Cause Dementia: A Systematic Review and Meta-analysis.
Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Tooth loss as a factor associated with deterioration of quality and increase in sleep duration: analysis of the 2016-2017 Chilean National Health Survey.BMC oral health · 2026Article
- Cognition and psychomotor vigilance in treated sleep apnea patients with and without daytime sleepiness: the MAGNETO study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.EXCLI journal · 2026Review
- Sleep duration, depressive symptoms, and postoperative delirium: a mediation analysis.Frontiers in psychiatry · 2026Article
- Association of Excessive Daytime Sleepiness With Long-Term Incident Dementia: The Role of β-Amyloid and White Matter Injury.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundExcessive daytime sleepiness (EDS) and long sleep duration are common in older adults and are related to dementia pathology. This study aims to assess the effect of EDS and long sleep duration on all-cause dementia and cognitive decline.
methodsWe identified longitudinal studies assessing the relationship between EDS and/or long sleep duration on cognitive decline/dementia published up to March 24, 2024 from MEDLINE, Embase, PsyINFO, the Cochrane Central Register of Controlled Trials, and PubMed. The inverse-variance-weighted average method and Bayesian multilevel regression models were used to test the effect of EDS and long sleep duration on cognitive decline and dementia risk.
resultsFifteen studies with 65 501 participants were recruited. Excessive daytime sleepiness was associated with increased risk of cognitive decline and all-cause dementia (risk ratio 1.26, 95% confidence interval [CI]: 1.13-1.41, and risk ratio 1.68, 95% CI: 1.07-2.66, respectively). Long sleep duration increased the risk of all-cause dementia by 29% (95% hazard ratio CI: 0.94-1.77, Pr [hazard ratio > 1] = 0.94); and cognitive decline by 13% (95% risk ratio, CI: 0.92-1.4). Dementia-free time at age 85 was 0.13 years shorter among long sleepers (Pr (∆ Restricted Mean Dementia-Free Time < 0) = 0.98).
conclusionsBoth EDS and long sleep duration were associated with increased risk of all-cause dementia. However, it remains unclear whether these are independent risk factors or merely reflect the same underlying pathological process. Further studies are needed to explore the interaction between these exposures on dementia and their potential as targets for dementia prevention.
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