Evidence map›Paper›PMID 40293920›Full record

ArticleCell reports2025

Staphylococcus aureus promotes strain-dependent immunopathology during cutaneous leishmaniasis through induction of IL-1β.

Victoria Lovins, Camila Farias Amorim, Nélida Robles, Sofía Murga-Garrido, Jamie Ting-Chun Pan, Tej P Singh, Erin DeNardo, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Leishmaniasis.Nature reviews. Disease primers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Victoria LovinsDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Camila Farias AmorimDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nélida RoblesDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sofía Murga-GarridoDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jamie Ting-Chun PanDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tej P SinghDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erin DeNardoDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lucas P CarvalhoLaboratório de Pesquisas Clínicas de Instituto de Pesquisas Gonçalo Muniz, Fiocruz, Bahia, Brazil.
Edgar M CarvalhoLaboratório de Pesquisas Clínicas de Instituto de Pesquisas Gonçalo Muniz, Fiocruz, Bahia, Brazil.
Phillip ScottDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: pscott@vet.upenn.edu.
Elizabeth A GriceDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: egrice@pennmedicine.upenn.edu.

Funding

Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Skin microbiome contributions to the pathogenesis of cutaneous leishmaniasisR01AI143790 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, PHILLIP SCOTT · 2019 to 2026
$6.0M
VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
Investigating the role of Staphylococcus aureus strain-level diversity on neutrophil recruitment and wound healing in a cutaneous leishmaniasis infectionF31AR079901 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOVINS, VICTORIA · 2021 to 2023
$128k
NIAID NIH HHS R01 AI143790NIAID NIH HHS T32 AI070077NIAMS NIH HHS F31 AR079901NIAMS NIH HHS P30 AR069589
6 · The paper itself

Abstract

Cutaneous leishmaniasis is a parasitic infection that causes a spectrum of pathology ranging from single, self-healing lesions to disfiguring chronic wounds. In severe disease, uncontrolled inflammation exacerbates tissue damage and delays healing, though the contributing factors are unclear. We previously observed that delayed healing was associated with Staphylococcus aureus in the lesional microbiota of patients with cutaneous leishmaniasis. To investigate how S. aureus impacts immunopathology during leishmania infection, we established a murine model of S. aureus colonization with clinical isolates followed by Leishmania infection. S. aureus triggered early production of interleukin (IL)-1β during Leishmania infection, which was critical for neutrophil recruitment and cutaneous inflammation. S. aureus isolates differentially induced IL-1β and neutrophil recruitment, and isolates that induced greater neutrophil recruitment were resistant to neutrophil killing and persisted longer. We reveal a mechanism whereby S. aureus mediates immunopathology during cutaneous leishmaniasis, suggesting IL-1β as a promising immunomodulatory target for non-healing infections.

Indexed as

Interleukin-1betaLeishmaniasis, CutaneousStaphylococcus aureusAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLNeutrophil InfiltrationNeutrophilsStaphylococcal InfectionsInterleukin-1betaCP: Microbiologycutaneous leishmaniasisLeishmaniamicrobiotaskin infectionStaphylococcus aureus

Identifiers

PMID40293920
PMCPMC12175678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.