Evidence map›Paper›PMID 40293685›Full record

ArticleNeuroscience bulletin2025

Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.

Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meng-Ge Li *Center of Translational Medicine, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, 215600, China.
Shu-Ting Qu *Department of Gastroenterology, Suzhou Dushu Lake Hospital, The Forth Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Yang YuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Zhenhua XuCenter of Translational Medicine, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, 215600, China.
Fu-Chao ZhangJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Yong-Chang LiCenter of Translational Medicine, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, 215600, China. yongchangli@suda.edu.cn.ORCID http://orcid.org/0009-0007-8694-5150
Rong GaoCenter of Translational Medicine, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, 215600, China. gaorong1234@suda.edu.cn.ORCID http://orcid.org/0009-0004-9757-2036
Guang-Yin XuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China. guangyinxu@suda.edu.cn.ORCID http://orcid.org/0000-0002-5465-5892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the visceral organs and their associated nervous pathways. Increasing evidence suggests that imbalances in central nervous system function play an essential role in the progression of visceral pain, but the exact mechanisms underlying the neural circuitry and molecular targets remain largely unexplored. In the present study, the ventral tegmental area (VTA) was shown to mediate visceral pain in mice. Visceral pain stimulation increased c-Fos expression and Ca

Indexed as

Chronic PainNeuronsReceptors, N-Methyl-D-AspartateVentral Tegmental AreaVisceral PainAnimalsGlutamic AcidMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosUp-RegulationGlutamic AcidNR2A NMDA receptorProto-Oncogene Proteins c-fosReceptors, N-Methyl-D-AspartateChronic visceral painGlutamatergic neuronsIrritable bowel syndromeNMDA receptor 2A subunitVentral tegmental area

Identifiers

PMID40293685
PMCPMC12698881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.