ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Risk factors for the development of hospital-acquired pneumonia in patients with carbapenem-resistant Acinetobacter baumannii respiratory colonization and the role of multisite colonization: a multicenter retrospective study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Article
- Site-specific and time-varying Acinetobacter colonization and risk of invasive infection in critically ill patients.Infection · 2026Article
- Beyond Colonization: Dynamic Risk Stratification and Clinical Decision-Making for MDR Gram-Negative Infections in Critically Ill Patients.Biomedicines · 2026Review
- Factors Associated with Short-Term Clinical Outcomes in ICU Patients with Carbapenem-ResistantJournal of clinical medicine · 2026Article
- Six Years ofAntibiotics (Basel, Switzerland) · 2026Article
- Risk factors for carbapenem-resistantJAC-antimicrobial resistance · 2026Article
- Antibiotic Resistance Patterns of Bacteria Involved in Colonization and/or Infection of Patients in Intensive Care Units in Northeastern Romania.Antibiotics (Basel, Switzerland) · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCarbapenem-resistant Acinetobacter baumannii (CRAB) infections are associated with high morbidity and mortality rates. Furthermore, the role of CRAB respiratory colonization, including multisite colonization, has not yet been adequately highlighted in critically ill patients. MATERIALS AND
methodsIn this retrospective multicenter study, conducted in 4 different Italian hospitals, patients with CRAB respiratory colonization +/- other site who developed or did not develop clinically significant pneumonia from December 2015 to December 2023 were enrolled. The primary objective of the study was to identify risk factors associated with the development of pneumonia.
results760 patients were enrolled; among them, 392 (51.5%) developed pneumonia, while 304 (39.9%) patients presented multisite colonization. Overall, in-hospital mortality was 76.3% with a higher mortality (79.6%) in patients who developed pneumonia (p = 0.033). In logistic regression analysis, factors associated with the development of pneumonia included: age, immunosuppressive therapy, COPD, ventilatory support and multisite colonization. A score was developed with AUC 0.72, CI95% 0.68-0.75, p < 0.001 and a sensitivity of 79% and specificity of 55% with a score > 2 and a maximum score of 10 points. Multisite colonization was recorded more frequently in patients who developed pneumonia (51%, p < 0.001). Finally, Kaplan-Meier curves showed a significantly reduced survival at 30 days (p = 0.005) and throughout the hospital stay (p = 0.002) in patients with multisite colonization.
conclusionsThis study highlights the risk factors associated with the development of pneumonia in patients already colonized by CRAB. Multisite colonization showed an important role as a risk factor for the development of pneumonia and for its correlation with mortality. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.