Evidence map›Paper›PMID 40293616›Full record

ReviewCurrent medical science2025

Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders.

Yi-Qing Rao, Zi-Yu Zhou, Zi-Qi Yang, Meng-Xin Liu, Xiao-Yu Gan, Xue-Fei Hu, Hong-Yang Wang, Hao Li, Man Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Qing RaoSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zi-Yu ZhouSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zi-Qi YangSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Meng-Xin LiuSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xiao-Yu GanSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xue-Fei HuTraditional Chinese Medicine, School of Medicine, Acupuncture Research Institute, Jianghan University, Wuhan, 430056, China.
Hong-Yang WangSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hao LiSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China. 906242910@qq.com.
Man LiSchool of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China. liman73@mails.tjmu.edu.cn.ORCID http://orcid.org/0000-0003-4041-0437

Funding

National Natural Science Foundation of China 82374584National Natural Science Foundation of China 82405550
6 · The paper itself

Abstract

Anxiety disorders, characterized by persistent apprehension, somatic symptoms and fatigue, are leading causes of disability worldwide. The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacological strategy, with evidence supporting its effectiveness in alleviating anxiety across diverse conditions. This review synthesizes current research to clarify the molecular mechanisms through which aerobic exercise ameliorates anxiety in terms of the effects of exercise on the hypothalamic-pituitary-adrenal (HPA) axis, the hepatic-brain axis and epigenetics; electroencephalographic alterations; inflammatory pathways; the balance between oxidative and nitrogenous stress; various substances, such as brain-derived neurotrophic factor (BDNF), atrial natriuretic peptide (ANP), and opioid peptides; and the 5-HT2C receptor and cannabinoid receptor type-1 (CB1R), among others, reflecting the positive modulatory effects of aerobic exercise on anxiety. As a non-pharmacological intervention, aerobic exercise has been demonstrated to be useful in a variety of medical applications and has considerable potential for ameliorating symptoms of anxiety.

Indexed as

Anxiety DisordersExerciseExercise TherapyAnimalsBrain-Derived Neurotrophic FactorEpigenesis, GeneticHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemBrain-Derived Neurotrophic FactorAerobic exerciseAnxiety disordersMolecular mechanismsTherapeutic interventions

Identifiers

PMID40293616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.