Evidence map›Paper›PMID 40293569›Full record

ArticleExperimental brain research2025

Effects of experimentally induced lumbar nociception on trunk motor control in the rat during locomotion.

Fangxin Xiao, Wendy Noort, Juliette Lévénez, Jia Han, Jaap H van Dieën, Huub Maas

Abstract read
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In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangxin XiaoDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands.ORCID http://orcid.org/0000-0003-4862-4974
Wendy NoortDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands.
Juliette LévénezDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands.
Jia HanCollege of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-3071-420X
Jaap H van DieënDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands.ORCID http://orcid.org/0000-0002-7719-5585
Huub MaasDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands. h.maas@vu.nl.ORCID http://orcid.org/0000-0002-2304-2735

Funding

China Scholarship Council 202008310141
6 · The paper itself

Abstract

Nociception resulting in pain perception might be one of the factors contributing to the motor control changes in people with low-back pain. However, limited evidence exists regarding the effects of acute pain on trunk motor control during locomotion. This study aimed to evaluate the effects of hypertonic saline induced nociception on trunk movement and back muscle activity during locomotion in a rat model. Spine and pelvis kinematics, EMG signals from bilateral multifidus (MF) and medial longissimus (ML) muscles of the rats were collected during treadmill locomotion before and after hypertonic saline (5.8%) injection into the MF. We found that both the locomotion and EMG patterns remained unchanged after hypertonic saline injection. No significant changes were found in stride duration, pelvic, lumbar and spine angle changes, variability, or movement asymmetry. The overall EMG activation patterns and intermuscular coordination remained unchanged after hypertonic saline injection and there was synchronized activation of bilateral MF muscles with two peaks per stride cycle, and alternating activation of left and right ML. The only significant effects of hypertonic saline injection were the decrease in the normalized peak amplitude of the left MF and EMG variability in right ML, no effects were detected in other EMG outcomes or muscles. These results suggest that the changes in EMG activity reflect localized neuromuscular response to nociception rather than broader alterations in control of locomotion.

Indexed as

LocomotionNociceptionParaspinal MusclesAnimalsBiomechanical PhenomenaDisease Models, AnimalElectromyographyMaleRatsRats, Sprague-DawleySaline Solution, HypertonicSaline Solution, HypertonicAnimal modelElectromyography (EMG)GaitLocomotionNeuromuscular controlNociception

Identifiers

PMID40293569
PMCPMC12037427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.