ArticleLasers in medical science2025
Effect of ultrasonic agitation of methylene blue during the antimicrobial photodynamic therapy in reducing viable cells from a multispecies biofilm and endotoxins: an in vitro study.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of oxidative therapies in mature oral biofilms: A systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
To evaluate the effect of the agitation of an ultrasonic photosensitizer during the antimicrobial photodynamic therapy (aPDT) in reducing multispecies biofilm composed of E. faecalis, C. albicans, and E. coli and endotoxins (LPS) within the root canals. Thirty lower premolars were contaminated and randomly divided into three groups (n = 10). Group 1 (G1) used saline solution as a control, G2 (aPDT) used a photosensitizer (0.005% methylene blue with 3 min) applied into the root canal followed by a red laser (100 mW power, 9 J of energy, for 90 s), and G3 (aPDT + U) used 0.005% methylene blue activated by ultrasound for 20 s followed by the application of a red laser as described in G2. The effectiveness of each protocol was determined through colony forming units per milliliter count (CFU/mL), and the levels of LPS were quantified by using the Limulus Amoebocyte Lysate technique. The data was statistically analyzed at a 5% level of significance. Viable bacteria were detected in all three groups, with a mean of 2.82 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.