Evidence map›Paper›PMID 40293534›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Factors responsible for the decline in physical fitness during neoadjuvant chemotherapy in older patients with esophageal cancer: an exploratory prospective cohort study.

Tsuyoshi Harada, Tetsuya Tsuji, Junya Ueno, Nobuko Konishi, Takumi Yanagisawa, Nanako Hijikata, Aiko Ishikawa, Kakeru Hashimoto, Hitoshi Kagaya, Noriatsu Tatematsu and 4 more

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tsuyoshi HaradaDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. tsuyoshi6167@gmail.com.
Tetsuya TsujiDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Junya UenoDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Nobuko KonishiDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Takumi YanagisawaDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Nanako HijikataDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Aiko IshikawaDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Kakeru HashimotoDepartment of Rehabilitation, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Hitoshi KagayaDepartment of Rehabilitation, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Noriatsu TatematsuDepartment of Integrated Health Sciences, Nagoya University, Nagoya, Aichi, Japan.
Sadamoto ZendaDepartment of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Daisuke KotaniDepartment of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Takashi KojimaDepartment of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Takeo FujitaDepartment of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Funding

Japan Health Research Promotion Bureau 2023-younger-12
6 · The paper itself

Abstract

purposeThe decline in physical fitness during neoadjuvant chemotherapy (NAC) impacts postoperative pneumonia and survival in older patients with locally advanced esophageal cancer (LAEC). However, information is lacking on the clinical mechanisms underlying the decline in physical fitness during NAC in older patients. This study investigated the factors responsible for the decline in physical fitness during NAC in older patients with LAEC.

methodsThis was a single-center exploratory prospective cohort study. A total of 80 patients with LAEC aged ≥ 65 years who were scheduled for curative esophagectomy after NAC were consecutively enrolled between October 2021 and December 2023. The decline in the incremental shuttle walking test (ΔISWT; ΔISWT = pre-NAC (m) - post-NAC (m)) was calculated to assess physical fitness. Significant factors responsible for ΔISWT were detected using a multivariate regression model. Statistical significance was two-tailed at p < 0.05.

resultsA total of 69 patients (mean age, 72.9 years) were analyzed. The mean ISWT distances before and after NAC were 418.7 m and 353.5 m, respectively; the mean ΔISWT was 65.2 m. Significant responding factors for the decline in physical fitness during NAC were changes in skeletal muscle mass index (SMI; adjusted coefficient - 14.239 cm

conclusionThis prospective cohort study found that the significant factors for the decline in physical fitness during NAC were loss of skeletal muscle mass and decreased Hb during NAC in older patients with LAEC.

Indexed as

Esophageal NeoplasmsNeoadjuvant TherapyPhysical FitnessAgedAged, 80 and overEsophagectomyFemaleHumansMaleProspective StudiesWalk TestChemotherapyEsophageal cancerGeriatric oncologyPhysical fitness

Identifiers

PMID40293534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.