Evidence map›Paper›PMID 40293529›Full record

ArticleCellular and molecular life sciences : CMLS2025

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Wan-Peng Lu, Yong-da Liu, Zhi-Fa Zhang, Jia Liu, Jing-Wen Ye, Si-Yun Wang, Xing-Yi Lin, Yi-Ran Lai, Jie Li, Sui-Yi Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Hypoxia-mediated mJournal of translational medicine · 2025
    Review
  5. Review
  6. mCancer cell international · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wan-Peng Lu *Department of Medical Genetics, Naval Medical University, Shanghai, China.
Yong-da Liu *Department of Medical Genetics, Naval Medical University, Shanghai, China.
Zhi-Fa Zhang *Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Jia Liu *Department of Hematology, Affiliated Hospital of Hebei University, Baoding, China.
Jing-Wen YeDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Si-Yun WangDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Xing-Yi LinDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Yi-Ran LaiDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Jie LiDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Sui-Yi LiuDepartment of Medical Engineering, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China. liusuiyi81@126.com.
Ji-Hang YuanDepartment of Medical Genetics, Naval Medical University, Shanghai, China. jihangyuan@smmu.edu.cn.ORCID http://orcid.org/0000-0003-1297-7743
Xiao-Ting ZhuDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhuxiaoting127@shsmu.edu.cn.

Funding

National Natural Science Foundation of China 32470973National Natural Science Foundation of China 81972738National Natural Science Foundation of China 82422059National Natural Science Foundation of China 92374119Science and Technology Innovation Action Plan of Shanghai 22140902100University Experimental Technology Team Construction Plan of Shanghai University Experimental Technology Team Construction Plan of Shanghai
6 · The paper itself

Abstract

Liver metastases are frequently observed in various malignancies, including hepatocellular carcinoma, colorectal cancer, pancreatic cancer, and melanoma. As hepatic resident macrophages, Kupffer cells play a crucial role in resisting liver metastasis by phagocytosing and clearing invading tumor cells. However, the molecular mechanisms regulating Kupffer cell phagocytosis and liver metastasis remain largely unknown. Here, we demonstrate that the MIR670 host gene (MIR670HG) significantly suppresses tumor liver metastasis by enhancing phagocytosis of various tumor cells by Kupffer cells. CD24 was identified as a downstream target and critical mediator of MIR670HG in promoting Kupffer cell phagocytosis and inhibiting tumor liver metastasis. Further investigations revealed that MIR670HG interacts with the m

Indexed as

Kupffer CellsLiver NeoplasmsMicroRNAsPhagocytosisAnimalsCell Line, TumorDNA MethylationGene Expression Regulation, NeoplasticHumansMaleMiceMixed Function OxygenasesPromoter Regions, GeneticProto-Oncogene ProteinsRNA-Binding ProteinsFXR1 protein, humanMicroRNAsMixed Function OxygenasesProto-Oncogene ProteinsRNA-Binding ProteinsTET1 protein, humanCancerEpigenetic modificationsInnate immunityN 6-methyladenosineNoncoding RNAPhagocytosis checkpoint

Identifiers

PMID40293529
PMCPMC12037464

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.