Evidence map›Paper›PMID 40293516›Full record

ArticleJournal of molecular modeling2025

Theoretical study of 2D cancer drug nanocarriers based on calcium chloride.

Walid Iken, Hayat El Ouafy, Mouna Aamor, Loubna Halil, Mouad Boutkbout Nait Moudou, Soukaina Naciri, Mohamed Reda Chriyaa, Tarik El Ouafy

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Article in Journal of molecular modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Walid IkenLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Hayat El OuafyLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Mouna AamorLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Loubna HalilLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Mouad Boutkbout Nait MoudouLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Soukaina NaciriLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Mohamed Reda ChriyaaLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Tarik El OuafyLaboratory of Engineering in Chemistry and Physics of Matter, Faculty of Medicine and Pharmacy, Sultan Moulay Slimane University, Beni Mellal, Morocco. tarikelouafy@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThis study aims to use two-dimensional nanocarriers composed of cisplatin and fluorouracil molecules adsorbed on the surface of calcium chloride crystals. We found that cisplatin molecules release an alkaline ammonia molecule, neutralizing the acidic environment of cancerous tumors through acid-base interactions. This behavior is similar to the enzyme urease, which has shown good results in cancer treatment. The compounds cisplatin/CaCl

methodsThe calculations were performed using the Quantum ESPRESSO software and density functional theory (DFT). The model compounds were optimized using the PBE functional combined with the vdw-DF3 functional to correct for dispersion forces in van der Waals interactions. The calcium chloride crystal was cut using VESTA software.

Indexed as

Antineoplastic AgentsCalcium ChlorideCisplatinDrug CarriersNanoparticlesDensity Functional TheoryFluorouracilHumansModels, MolecularAntineoplastic AgentsCalcium ChlorideCisplatinDrug CarriersFluorouracilCisplatinCrystalsDFTEnzyme ureaseFluorouracil

Identifiers

PMID40293516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.