ArticleBioprocess and biosystems engineering2025
Aegle marmelos-mediated zinc oxide nanoparticles for mosquito control, cancer therapy, and antibacterial applications.
Article in Bioprocess and biosystems engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
The study investigated the synthesis and characterization of zinc oxide nanoparticles (Am-ZnO-NPs) using Aegle marmelos leaves and their mosquitocidal, antioxidant, and anticancer efficacy. Am-ZnO-NPs were synthesized via combustion method under optimized conditions, including 5% plant extract, temperature of 70 °C, a contact time of 60 min, and pH of 10. The resulting nanoparticles were characterized using advanced analytical techniques. The Am-CuO-NPs were hexagonal wurtzite in shape and had an average particle size of 37.44 nm. The Am-CuO-NPs are highly stable with a surface charge of - 26.77 mV. Gas chromatography-mass spectrometry (GC-MS) analysis identified several compounds with insecticidal, antioxidant, and anticancer properties, including hexadecenoic acid, ethyl ester (25.61%), 9,12-octadecadienoic acid, ethyl ester (12.64%), and 9,12,15-octadecatrienoic acid, ethyl ester (6.31%). The aqueous extract of A. marmelos (100 µg/mL) demonstrated the highest larvicidal (57.33%) and pupicidal (42.67%) activities compared to other solvent extracts. In contrast, Am-ZnO-NPs exhibited relatively higher larvicidal activity (86.67%) and pupicidal (56.00%) at 10 µg/mL. The nanoparticles also inhibited the activities of acetylcholinesterase (AChE) and carboxylesterases and reduced the total protein (TP) levels in Ae. aegypti larvae. Further, both the aqueous leaf extract and Am-ZnO-NPs were effective in scavenging DPPH free radicals, achieving 76% and 94% inhibition, respectively, at a concentration of 125 µg/mL. Am-ZnO-NPs also exhibited cytotoxicity, induced cell cycle arrest, enhanced cell adhesion, and promoted apoptosis in L-132 lung cancer cell lines. Further, the Am-ZnO-NPs display potent antibacterial activity against clinical pathogens. These results highlight the role of phytochemicals in A. marmelos leaves for their effective biological activities.
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