Evidence map›Paper›PMID 40293460›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Erythropoietin resistance among pediatric patients on chronic hemodialysis: A cross-sectional study.

Rasha Helmy, Fatina I Fadel, Rasha E Galal, Amira M Mohammed, Shaimaa Sayed

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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Rasha HelmyPediatric Department, Faculty of Medicine, Cairo University, 4 Extension of Nobar Street, Cairo, Egypt.
Fatina I FadelPediatric Department, Faculty of Medicine, Cairo University, 4 Extension of Nobar Street, Cairo, Egypt.
Rasha E GalalPediatric Department, Faculty of Medicine, Cairo University, 4 Extension of Nobar Street, Cairo, Egypt.
Amira M MohammedPediatric Department, Faculty of Medicine, Cairo University, 4 Extension of Nobar Street, Cairo, Egypt.
Shaimaa SayedPediatric Department, Faculty of Medicine, Cairo University, 4 Extension of Nobar Street, Cairo, Egypt. shaimaasayed@kasralainy.edu.eg.ORCID 0000-0002-9009-165X

Funding

The Egyptian Knowledge Bank (EKB)The Science, Technology & Innovation Funding Authority (STDF)
6 · The paper itself

Abstract

backgroundThe erythropoietin resistance index (ERI) is an accurate indicator of erythropoietin (EPO) resistance and is related to a worse prognosis in patients on hemodialysis (HD). ERI is simple, cheap and could be calculated easily in children receiving HD. We aimed to assess the EPO resistance in children with kidney failure on regular HD.

methodsAn analytical cross-sectional study was conducted on 80 children with kidney failure on regular HD. They were assessed by history taking and laboratory investigations including complete blood count, C- reactive protein (CRP), iron, ferritin, parathyroid hormone and serum electrolytes. ERI was calculated.

resultsThe study included 80 patients; 41 (51.2%) were male. The mean age of the study group was 8.86 ± 2.76 years. Sixty-three patients (78.8%) were on iron therapy. Mean ERI was 28.87 ± 10.62. The ERI was significantly positively correlated with age (r = 0.242; P = 0.031), EPO dose (r = 0.290; P = 0.001) and CRP (r = 0.219; P = 0.049). The ERI had a significantly negative correlation with KT/V (r = - 0.262; P = 0.019), hemoglobin level (r = - 0.265; P = 0.001) and platelet count (r = - 0.254; P = 0.023).

conclusionsErythropoietin resistance is associated with many risk factors, including high CRP and low KT/V. Inadequate HD is the most important risk factor for EPO resistance in children on chronic HD. Adequate HD is considered as a protective measure against EPO resistance.

Indexed as

AnemiaDrug ResistanceErythropoietinKidney Failure, ChronicRenal DialysisAdolescentChildChild, PreschoolC-Reactive ProteinCross-Sectional StudiesFemaleFerritinsHumansMaleC-Reactive ProteinErythropoietinFerritinsErythropoietin resistanceErythropoietin resistance indexHemodialysisKidney failurePediatrics

Identifiers

PMID40293460
PMCPMC12549759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.