Evidence map›Paper›PMID 40293341›Full record

ArticleChemistry & biodiversity2025

Green Propolis Extract-Mediated Synthesis of Biogenic Silver Nanoparticles: In Vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex Vivo Irritation Testing.

Erica Tirzah S Lima, Victoria L S Santos, Wanessa J S Mota, Frederico S Martins, Ricardo L C de Albuquerque-Junior, André L S Santos, Simone S C Oliveira, Jéssica A de Lima, Adriana de Jesus Santos, Cochiran P Dos Santos and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erica Tirzah S LimaInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.
Victoria L S SantosInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.
Wanessa J S MotaInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.
Frederico S MartinsSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Ricardo L C de Albuquerque-JuniorDepartment of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil.
André L S SantosDepartment of General Microbiology, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Simone S C OliveiraDepartment of General Microbiology, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Jéssica A de LimaApis Flora, Rua Triunfo, Ribeirão Preto, Brazil.
Adriana de Jesus SantosInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.
Cochiran P Dos SantosDepartment of Physics and Materials Science and Engineering, Federal University of Sergipe, São Cristóvão, Brazil.
Sona JainDepartment of Morphology, Federal University of Sergipe, São Cristóvão, Brazil.
Eliana B SoutoUCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Ireland.
Juliana C CardosoInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.
Patrícia SeverinoInstitute of Research and Technology, University Tiradentes, Aracaju, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs-PRO). Before nanoparticles synthesis, a hydroethanolic green propolis extract (GPE) was obtained through ultrasound-assisted extraction and characterized by high-performance liquid chromatography, revealing the artepilin C as the most abundant phenolic compound in its composition, followed by 4,5-dicaffeoylquinic acid and drupanin. The analysis of synthesized AgNPs by UV-Vis spectroscopy showed a characteristic absorption band at 430 nm. Dynamic light scattering analysis revealed mean hydrodynamic particle sizes ranging from 88 to 115 nm, with a polydispersity index between 0.229 ± 0.006 and 0.365 ± 0.054. Fourier-transform infrared spectroscopy confirmed that functional groups present in GPE contribute to the reduction and stabilization of AgNPs. Differential scanning calorimetry and transmission electron microscopy confirmed that AgNPs were obtained. GPE showed leishmanicidal activity against promastigote forms of Leishmania amazonensis, with a half-maximal inhibitory concentration (IC

Indexed as

Anti-Bacterial AgentsAntiprotozoal AgentsMetal NanoparticlesPropolisSilverAnimalsCell SurvivalDose-Response Relationship, DrugEscherichia coliGreen Chemistry TechnologyLeishmaniaMicrobial Sensitivity TestsParasitic Sensitivity TestsParticle SizeStaphylococcus aureusAnti-Bacterial AgentsAntiprotozoal AgentsPropolisSilverantileishmanialantimicrobialgreen propolisHen's egg chorioallantoic membranesilver nanoparticles

Identifiers

PMID40293341
PMCPMC12435430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.