Observational studyDiabetes/metabolism research and reviews2025
Seasonal Variations in HbA1c and Body Composition: A Sex-Specific Analysis in Adolescents With Type 1 Diabetes.
Observational study in Diabetes/metabolism research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Seasonal Variations in Estimated Whole Blood Viscosity Associated with HbA1c: Evidence from Retrospective Pathology Review for Diabetes Management.International journal of molecular sciences · 2025Observational
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11 authors.
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Abstract
backgroundCircannual fluctuations in glycated haemoglobin (HbA1c) levels are recognized among adults, but comparable changes and contributing factors in adolescents with type 1 diabetes (T1D) have not been investigated in depth.
objectivesTo examine the seasonal changes in HbA1c and their association with body composition in youth with T1D.
methodsThis retrospective observational study included adolescents with T1D followed at our paediatric diabetes centre (2021-2023). Seasonal means were calculated for two periods (winter-spring: December to May and summer-autumn: June to November), and ΔHbA1c was calculated as the difference between the values. The patients' body composition (via bioelectrical impedance analysis (BIA)) data were reviewed, and correlation analyses were performed between sex- and age-adjusted z-scores of body composition components [appendicular muscle mass (ASMM) and fat mass (FATM)] and ΔHbA1c.
resultsThe seasonal means of HbA1c calculated for 259 adolescents with T1D (56% male, mean age: 16.01 ± 2.23 years) were significantly higher during winter-spring compared to summer-autumn (7.75% vs. 7.24%, p < 0.001, CI: 0.42-0.57), (61.16 mmol/mol vs. 55.72 mmol/mol, respectively p < 0.001, CI: 4.64-6.23). ΔHbA1c displayed a sex-specific association with body composition components in 102 patients (50% males) who underwent BIA. The correlation was significant for only ASMM z-scores in boys (r = 0.277, p = 0.049), while both the ASMM and FATM z-scores significantly correlated with ΔHbA1c (r = 0.301, p = 0.032 and r = 0.284, p = 0.043, respectively) in girls.
conclusionsThere is a seasonal variation in HbA1c levels in adolescents with T1D, with higher values during winter-spring. The link between seasonal variability and body composition components varied by sex, indicating a need for sex-specific strategies in adolescent diabetes management.
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