ReviewPolymers2025
Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review.
Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Process-Driven Modulation of Structure and Cytocompatibility in Electrospun Silk Fibroin Membranes through Controlled Degumming.ACS omega · 2026Article
- Valorization of Silkworm Cocoons into Sustainable Nanomaterials: Applications and Challenges.ACS biomaterials science & engineering · 2026Review
- 3D-Printed Porous Titanium Alloy Scaffolds Incorporated With Tetramethylpyrazine-Loaded Composite Hydrogels Enhance Angiogenesis and Bone Repair for Femoral Head Osteonecrosis.Advanced healthcare materials · 2026Article
- Effect of Sterilization Methods on the Physicochemical Properties of Silk Fibroin Hydrogels.Polymers · 2026Article
- Silk-Derived 3D-Bioprinted Scaffolds for Neural Repair and Nerve Regeneration: A Comprehensive Review.Life (Basel, Switzerland) · 2026Review
- Review
- Impact of the Chronic Ischemic Stroke Microenvironment on Silk Fibroin Hydrogel Biodegradation andACS omega · 2026Article
- Biocompatible Electrospun Biomaterials for Advancing Thermoregulating Wearable Sensors in Next-Generation Smart Textiles.Journal of functional biomaterials · 2026Review
- Review
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Biomimetic Three-Dimensional (3D) Scaffolds from Sustainable Biomaterials: Innovative Green Medicine Approach to Bone Regeneration.Journal of functional biomaterials · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Silk fibroin (SF), a natural high-molecular-weight fiber protein extracted from silk, has demonstrated immense potential in bone tissue repair and regeneration due to its exceptional physicochemical properties. Silk fibroin can be processed into various scaffold forms using diverse fabrication techniques, combined with other biomaterials to create composite structures, or chemically modified to address a wide range of bone defect conditions. This review provides a comprehensive examination of the role of silk fibroin and its composites in bone tissue engineering, with particular emphasis on preclinical studies investigating various silk fibroin-based composite scaffolds in osteogenesis. Additionally, it discusses the current status and challenges in preparing silk fibroin scaffolds tailored to bone tissue defects and explores innovative approaches such as silk fibroin membranes, hydrogels, and 3D-printed constructs. The review begins with an introduction to bone biology, including its composition, structure, healing mechanisms, and the development of bone repair materials. It then delves into the unique properties of silk fibroin, including its composition, structure, and physicochemical attributes, which make it an ideal candidate for bone tissue engineering. This review provides valuable insights into their design, fabrication, and application by critically analyzing recent advancements in silk fibroin-based scaffolds and their functional modifications. Finally, it offers a forward-looking perspective on the future development and translational potential of silk fibroin and its composites in the field of bone repair materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.