ArticleDevelopment (Cambridge, England)2025
Developmental dynamics of marmoset prefrontal cortical SST and PV interneuron networks highlight primate-specific features.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026Review
- Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates.bioRxiv : the preprint server for biology · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3.Developmental neurobiology · 2026Article
- Developmental trajectories of somatostatin-positive interneurons in the human auditory cortex from migration to maturation.Communications biology · 2026Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Selective enrichment of TCF4 in GABAergic neurons during postnatal primate development.Frontiers in neuroanatomy · 2026Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications.Journal of neurochemistry · 2025Review
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6 authors.
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Abstract
The primate prefrontal cortex (PFC) undergoes protracted postnatal development, crucial for the emergence of cognitive control and executive function. Central to this maturation are inhibitory interneurons (INs), particularly parvalbumin-expressing (PV+) and somatostatin-expressing (SST+) subtypes, which regulate cortical circuit timing and plasticity. While rodent models have provided foundational insights into IN development, the trajectory of postmigratory maturation in primates remains largely uncharted. In this study, we characterized the expression of PV, SST, the chloride transporter KCC2, and the ion channels Kv3.1b and Nav1.1 across six PFC regions (areas 8aD, 8aV, 9, 46, 11 and 47L) in the postnatal marmoset. We report a prolonged maturation of PV+ INs into adolescence, accompanied by progressive upregulation of ion channels that support high-frequency firing. In contrast, SST+ INs show a postnatal decline in density, diverging from rodent developmental patterns. These findings reveal distinct, cell type-specific maturation dynamics in the primate PFC and offer a developmental framework for understanding how inhibitory circuit refinement may underlie vulnerability to neurodevelopmental disorders.
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