Evidence map›Paper›PMID 40292579›Full record

ArticlePolymers2025

Quantification of Hydrogen Peroxide in PVP and PVPVA Using

Isha Saraf, Varun Kushwah, Bernd Werner, Klaus Zangger, Amrit Paudel

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isha SarafResearch Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
Varun KushwahResearch Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
Bernd WernerInstitute of Chemistry, University of Graz, Heinrichstr. 28, 8010 Graz, Austria.
Klaus ZanggerInstitute of Chemistry, University of Graz, Heinrichstr. 28, 8010 Graz, Austria.ORCID 0000-0003-1682-1594
Amrit PaudelResearch Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.ORCID 0000-0002-3325-7828

Funding

Austrian FFG NA
6 · The paper itself

Abstract

objectivePeroxides in pharmaceutical products and excipients pose risks by oxidizing drug molecules, leading to potential toxicity and reduced efficacy. Accurate peroxide quantification is essential to ensure product safety and potency. This study explores the use of quantitative proton nuclear magnetic resonance (

methods

resultsPeroxide levels varied among different grades of PVP and PVPVA, as well as between vendors. Furthermore, manufacturing processes influenced the hydrogen peroxide content in selected excipients. These variations highlight the importance of controlling peroxide levels in raw materials and during production.

conclusions

Indexed as

1H qNMRexcipientperoxidespolymerreactive impurities

Identifiers

PMID40292579
PMCPMC11945108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.