Evidence map›Paper›PMID 40292576›Full record

ArticlePolymers2025

Fabrication of Radiopaque, Drug-Loaded Resorbable Polymer for Medical Device Development.

Sophie T Melancon, Erin Marie San Valentin, Dominic Karl M Bolinas, Marvin R Bernardino, Archana Mishra, Gino Canlas, Gouthami Chintalapani, Megan C Jacobsen, Allan John R Barcena, Steven Y Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophie T MelanconDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0009-0002-1081-5775
Erin Marie San ValentinDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-5998-6423
Dominic Karl M BolinasDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-6762-1149
Marvin R BernardinoDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Archana MishraDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Gino CanlasDepartment of Chemistry, Lamar University, Beaumont, TX 77710, USA.
Gouthami ChintalapaniSiemens Medical Solutions USA, Inc., Malvern, PA 19355, USA.
Megan C JacobsenDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Allan John R BarcenaDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-5067-0334
Steven Y HuangDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-8860-5092

Funding

MD Anderson's Cancer Center Support Grant P30CA016672
6 · The paper itself

Abstract

Resorbable medical devices provide temporary functionality before degrading into safe byproducts. One application is absorbable inferior vena cava filters (IVCFs), which prevent pulmonary embolism in high-risk patients with contraindications to anticoagulants. However, current absorbable IVCFs are limited by radiolucency and local clot formation risks. This study aimed to develop radiopaque, drug-loaded resorbable IVCFs with enhanced imaging and therapeutic capabilities. Poly-p-dioxanone (PPDO) sutures were infused with gadolinium nanoparticles (GdNPs) and dipyridamole (DPA), an anti-thrombotic agent. GdNPs were synthesized with an average diameter of 35.76 ± 3.71 nm. Gd content was 371 ± 1.6 mg/g (PPDO-Gd) and 280 ± 0.3 mg/g (PPDO-Gd + DPA), while the DPA content was 18.20 ± 5.38 mg/g (PPDO-DPA) and 12.91 ± 0.83 mg/g (PPDO-Gd + DPA). Suture thickness (0.39-0.49 cm,

Indexed as

dipyridamolegadolinium nanoparticlesinferior vena cava filtersradiopacityresorbable medical device

Identifiers

PMID40292576
PMCPMC11945502

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.