ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Gray Matter Covariance Networks Associated With Parental Longevity-Results From the LonGenity Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).Neuropsychology · 2026Observational
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7 authors.
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Abstract
backgroundOlder adults with exceptional longevity-and their offspring-are protected from age-related diseases and have a prolonged health span. Prior research suggests that offspring of parents with exceptional longevity have larger temporal and sensorimotor cortices in mid to late-adulthood-but the association between brain health and parental longevity is not well understood in older adults. This study aimed to identify a gray matter volume pattern (or network) associated with parental longevity in older adults-and to determine if individual expressions of this gray matter pattern vary with cognitive performance.
methodsParticipants consisted of 139 older adults of Ashkenazi Jewish descent from the LonGenity study (M age 79.4 ± 6.5 years; 56.11% women). Eighty-four (60.4%) were offspring of parents with exceptional longevity and 55 (39.6%) were offspring of parents with usual survival. A gray matter network associated with parental longevity was derived with multivariate covariance-based analyses that were adjusted for potential confounders. Participant-specific expressions of this network were then regressed against cognitive test performances.
resultsThe derived gray matter covariance network associated with parental longevity was primarily composed of frontal, insular, and hippocampal regions. The extent to which older adults displayed this pattern was associated with overall cognition, Free Recall, Digit Symbol Substitution, Boston Naming, and Trail Making Test A performance.
conclusionsParental longevity is associated with a widespread network of brain regions in aging. This brain network also varies as a function of cognitive performance.
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