Evidence map›Paper›PMID 40292478›Full record

ReviewNutrients2025

Myths and Facts Regarding Low-Carbohydrate Diets.

Nina Teicholz, Steven M Croft, Ignacio Cuaranta, Mark Cucuzzella, Mariela Glandt, Dina H Griauzde, Karen Jerome-Zapadka, Tro Kalayjian, Kendrick Murphy, Mark Nelson and 9 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nina TeicholzIndependent Researcher, New York, NY 10024, USA.ORCID 0009-0008-4367-4861
Steven M CroftIndependent Researcher, Houston, TX 77074, USA.
Ignacio CuarantaIndependent Researcher, Rosario 2000, Argentina.
Mark CucuzzellaDepartment of Family Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Mariela GlandtOwnaHealth, New York, NY 10006, USA.
Dina H GriauzdeDepartment of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Karen Jerome-ZapadkaValley Gastroenterology Associates, Beaver Falls, PA 15010, USA.
Tro KalayjianGreenwich Hospital, Yale New Haven Health, Greenwich, CT 06830, USA.ORCID 0000-0001-5803-2804
Kendrick MurphyWestern North Carolina VA Health Care System, Asheville, NC 28805, USA.
Mark NelsonIndependent Researcher, Chicago, IL 60174, USA.
Catherine ShanahanRebel Well, LLC, Orlando, FL 32803, USA.
Jodi L NishidaThe Keto Prescription Clinic, Honolulu, HI 96734, USA.
Robert C OhDepartment of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
Naomi ParrellaDepartment of Family and Preventive Medicine, Rush Medical College, Chicago, IL 60612, USA.
Erin M SanerDepartment of Family & Community Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Shebani SethiMetabolic Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jeff S VolekDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-8702-0351
Micalla WillidenIndependent Researcher, Auckland 0618, New Zealand.
Susan WolverDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.ORCID 0000-0003-1364-5775

Funding

A multilevel intervention to support weight loss among individuals with prediabetes in primary care settingsK23DK123416 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRIAUZDE, DINA HAFEZ · 2020 to 2024
$962k
NIDDK NIH HHS K23 DK123416
6 · The paper itself

Abstract

As the prevalence of chronic diseases persists at epidemic proportions, health practitioners face ongoing challenges in providing effective lifestyle treatments for their patients. Even for those patients on GLP-1 agonists, nutrition counseling remains a crucial strategy for managing these conditions over the long term. This paper aims to address the concerns of patients and practitioners who are interested in a low-carbohydrate or ketogenic diet, but who have concerns about its efficacy, safety, and long-term viability. The authors of this paper are practitioners who have used this approach and researchers engaged in its study. The paper reflects our opinion and is not meant to review low-carbohydrate diets systematically. In addressing common concerns, we hope to show that this approach has been well researched and can no longer be seen as a "fad diet" with adverse health effects such as impaired renal function or increased risk of heart disease. We also address persistent questions about patient adherence, affordability, and environmental sustainability. This paper reflects our perspective as clinicians and researchers engaged in the study and application of low-carbohydrate dietary interventions. While the paper is not a systematic review, all factual claims are substantiated with citations from the peer-reviewed literature and the most rigorous and recent science. To our knowledge, this paper is the first to address potential misconceptions about low-carbohydrate and ketogenic diets comprehensively.

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicDietary CarbohydratesHumansPatient ComplianceDietary Carbohydratesdiabetesheart diseaseketogeniclow-carbohydrate dietobesity

Identifiers

PMID40292478
PMCPMC11944661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.