Evidence map›Paper›PMID 40292468›Full record

ArticleNutrients2025

Epigenetic Aging Acceleration in Obesity Is Slowed Down by Nutritional Ketosis Following Very Low-Calorie Ketogenic Diet (VLCKD): A New Perspective to Reverse Biological Age.

Andrea G Izquierdo, Paula M Lorenzo, Nicolás Costa-Fraga, David Primo-Martin, Gemma Rodriguez-Carnero, Carolina F Nicoletti, J Alfredo Martínez, Felipe F Casanueva, Daniel de Luis, Angel Diaz-Lagares and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrea G IzquierdoEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-0846-8834
Paula M LorenzoEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.ORCID 0000-0003-2704-2879
Nicolás Costa-FragaCancer Epigenomics, Epigenomics Unit, Translational Medical Oncology Group (ONCOMET), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Universidad de Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain.
David Primo-MartinCenter of Investigation of Endocrinology and Nutrition, Department of Endocrinology and Investigation, Medicine School, Hospital Clinico Universitario, University of Valladolid, 47011 Valladolid, Spain.
Gemma Rodriguez-CarneroEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.
Carolina F NicolettiApplied Physiology and Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05508-900, Brazil.
J Alfredo MartínezPrecision Nutrition Program, Research Institute on Food and Health Sciences IMDEA Food, CSIC-UAM, 28049 Madríd, Spain.ORCID 0000-0001-5218-6941
Felipe F CasanuevaEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-9052-8161
Daniel de LuisCenter of Investigation of Endocrinology and Nutrition, Department of Endocrinology and Investigation, Medicine School, Hospital Clinico Universitario, University of Valladolid, 47011 Valladolid, Spain.ORCID 0000-0002-1745-9315
Angel Diaz-LagaresCancer Epigenomics, Epigenomics Unit, Translational Medical Oncology Group (ONCOMET), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Universidad de Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain.
Ana B CrujeirasEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.ORCID 0000-0003-4392-0301

Funding

Instituto de Salud Carlos III CPII22/00008Instituto de Salud Carlos III PI20/00650Instituto de Salud Carlos III PI24/00549Xunta de Galicia-GAIN IN607B-20240301
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingCaloric RestrictionDiet, KetogenicEpigenesis, GeneticKetosisObesityAdultBody Mass IndexDNA MethylationFemaleHumansMaleMiddle Agedblood leukocytesbody weight lossDNA methylationepigenetic clockHannumHorvathketone bodiesLevinepersonalized therapyprecision medicine

Identifiers

PMID40292468
PMCPMC11945372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.