ArticleGeriatric orthopaedic surgery & rehabilitation2025
Genome-Wide Study of the UK Biobank Highlights the Importance of the Homeobox-C Gene Cluster in Hip Fracture Risk.
Article in Geriatric orthopaedic surgery & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Orthogeriatric care after hip fracture: the role of process reliability in improving outcomes.Journal of orthopaedic surgery and research · 2026Article
- Ceilings of treatment in hip fracture: a marker of vulnerability rather than a cause of mortality.European geriatric medicine · 2026Article
- Older adults' perspectives on big data use in hip fracture research: a qualitative study.BMC geriatrics · 2026Article
- From Anatomy to Innovation: Embedding Patient-Centered Design in Medical Education.JMIR medical education · 2026Article
- Rethinking body composition in vertebral fracture risk assessment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Bilateral Patellar Tendon Rupture in a 64-Year-Old Man: Possible Interaction of Inhaled Corticosteroids, Age and Mechanical Stress.Case reports in orthopedics · 2026Article
- Interpreting Blood Transfusion in Hip Fracture Surgery: Marker of Severity Rather Than Mediator of Harm? [Letter].Journal of blood medicine · 2026Article
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5 authors.
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Abstract
Introduction: Hip fractures are among the most common major orthopaedic injuries globally, with one in three women and one in twelve men projected to sustain a hip fracture in their lifetime. Identifying genetic factors that contribute to hip fracture risk could improve risk stratification and inform prevention strategies. This study aims to identify genetic variants associated with hip fracture susceptibility through a genome-wide association study (GWAS). Materials and Methods: A GWAS was undertaken using the UK Biobank to identify risk loci for hip fractures. Results: At the time of analysis, 2165 neck of femur fractures were identified among the 502 507 participants. Thirteen SNPs in five putative haplotypes were identified as significantly associated with hip fracture using the stringent GWAS threshold of 5E-8. Two of these loci appear to affect HOXC8, either by influencing the 3' UTR (rs4142680[T]) or via the miRNA hsa-miR-196a (rs11614913[T]). These two SNPs were also found to be expression quantitative trait loci for homeobox-C cluster genes (HOXC6, HOXC9, and HOXC-AS1). Conclusions: Polymorphisms affecting homeobox-C cluster genes influence hip fracture risk in the general population. Future research should focus on validating these genetic associations and exploring optimal therapeutic interventions that could mitigate fracture risk in subpopulations carrying these polymorphisms.
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