Evidence map›Paper›PMID 40292327›Full record

ArticleiScience2025

Neuroactive steroids activate membrane progesterone receptors to induce sex specific effects on protein kinase activity.

Abigail H S Lemons, Briana Murphy, Jake S Dengler, Seda Salar, Paul A Davies, Joshua L Smalley, Stephen J Moss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neurosteroids: a lifelong impact on brain health.Frontiers in behavioral neuroscience · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Abigail H S LemonsDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Briana MurphyDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Jake S DenglerDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Seda SalarDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Paul A DaviesDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Joshua L SmalleyDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.

Funding

Tufts Post-Baccalaureate Research Education ProgramR25GM066567 · NIGMS · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2002 to 2024
$5.7M
Mechanisms that determine Glutamine synthetase activity in the brainR01NS081986 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2012 to 2022
$3.7M
Studies on the structure of gamma-aminobutyric acid type A receptor subtypesR01MH118263 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2019 to 2023
$2.4M
Modulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0M
Deficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0M
Mechanisms that determine the activity of glutamine synthetase in the brainR21NS103865 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2018 to 2019
$454k
Determining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454k
NIGMS NIH HHS R25 GM066567NIMH NIH HHS R01 MH097446NIMH NIH HHS R01 MH118263NINDS NIH HHS R01 NS081986NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888NINDS NIH HHS R01 NS108378NINDS NIH HHS R21 NS103865NINDS NIH HHS R21 NS111338
6 · The paper itself

Abstract

Neuroactive steroids (NAS), which are synthesized in the brain from progesterone, exert potent effects on behavior and are used to treat postpartum depression, yet how these compounds induce sustained modifications in neuronal activity are ill-defined. Here, we examined the efficacy of NAS for membrane progesterone receptors (mPRs) δ and ε, members of a family of GPCRs for progestins that are expressed in the CNS. NAS increase PKC activity via the G

Indexed as

molecular biologyNeuroscience

Identifiers

PMID40292327
PMCPMC12032937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.