Evidence map›Paper›PMID 40292302›Full record

ArticleFrontiers in immunology2025

Protection against

Weiyan Zhu, Andreea Waltmann, Marguerite B Little, Kristie L Connolly, Kathryn A Matthias, Keena S Thomas, Mary C Gray, Aleksandra E Sikora, Alison K Criss, Margaret C Bash and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Virulence · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. PreclinicalFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Weiyan ZhuDivision of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
Andreea WaltmannDivision of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
Marguerite B LittleDepartment of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
Kristie L ConnollyDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, United States.
Kathryn A MatthiasLaboratory of Bacterial Polysaccharides, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Keena S ThomasDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States.
Mary C GrayDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States.
Aleksandra E SikoraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, United States.
Alison K CrissDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States.
Margaret C BashLaboratory of Bacterial Polysaccharides, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Andrew N MacintyreDepartment of Medicine, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States.
Ann E JerseDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, United States.
Joseph A DuncanDivision of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, United States.

Funding

Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Resources and Workforce Development for the Regional Biocontainment LaboratoriesUC7AI180254 · NIAID · DUKE UNIVERSITY · PI Herman F Staats · 2023 to 2026
$14.0M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
The Gonorrhea Vaccine Cooperative Research CenterU19AI144180 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI CHACKERIAN, BRYCE C · 2019 to 2023
$10.7M
The Atlantic Coast Sexually Transmitted Infection Cooperative Research Center (ACU19AI113170 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI JERSE, ANN E. · 2014 to 2018
$6.9M
Proteomics-Driven Reverse Vaccinology for GonorrheaR01AI117235 · NIAID · OREGON STATE UNIVERSITY · PI Aleksandra Elzbieta Sikora · 2015 to 2026
$6.7M
Regional Biocontainment Laboratories Facility and Building System Upgrades SupportG20AI167200 · NIAID · DUKE UNIVERSITY · PI STAATS, HERMAN F · 2021 to 2022
$6.6M
CTSA K12 Program at UNCK12TR004416 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michelle Hernandez, Jonathan J Juliano · 2023 to 2026
$6.5M
NCATS NIH HHS K12 TR004416NIAID NIH HHS G20 AI167200NIAID NIH HHS R01 AI117235NIAID NIH HHS T32 AI007001NIAID NIH HHS U19 AI113170NIAID NIH HHS U19 AI144180NIAID NIH HHS UC6 AI058607NIAID NIH HHS UC7 AI180254
6 · The paper itself

Abstract

Introduction: Limited protective immunologic responses to natural Methods: To study this, we immunized mice with two meningococcal OMV-containing vaccines known to accelerate clearance of Results: Mice immunized with 4CMenB or MC58 ΔABR demonstrated shortened courses of recovery of vaginal Discussion: Our findings suggest the cross-protection against gonococcal infection induced by different meningococcal OMV vaccines is likely multifactorial and mediated by different humoral and cellular immune responses induced by these two vaccines.

Indexed as

Bacterial Outer Membrane ProteinsCross ProtectionGonorrheaImmunity, CellularImmunity, HumoralMeningococcal VaccinesNeisseria gonorrhoeaeNeisseria meningitidisAnimalsAntibodies, BacterialCross ReactionsDisease Models, AnimalFemaleHumansMiceAntibodies, BacterialBacterial Outer Membrane ProteinsMeningococcal Vaccinescorrelates of protectionNeisseria gonorrhoeaeNeisseria meningitidisouter membrane vesicle (OMV)vaccine

Identifiers

PMID40292302
PMCPMC12021806

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.