ArticleAvicenna journal of phytomedicine
The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Pitavastatin-induced cholesterol deficiency elevates serum biomarkers associated with statin-related adverse effects in rats.Cardiovascular endocrinology & metabolism · 2025Article
- The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells.Cell division · 2025Review
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6 authors.
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Abstract
Objective: Animal studies have revealed that lipid accumulation in obese mice fed with a high-fat diet (HFD) leads to alterations in the structural and functional properties of cardiovascular tissues. The current study aimed to investigate apoptosis/anti-apoptotic markers in the heart tissue of rats fed with a HFD. Materials and Methods: Twenty-four male Wistar rats (weighing approximately 180 grams) were randomly divided into three groups (n=8 each group), including the control group (C), the high-fat diet group (HFD), and the high-fat diet + carvacrol group (HFD + Carva). Animals received a standard or HFD to induce obesity for three months. From day 61 to 90 in the HFD+Carva group, carvacrol was injected intraperitoneally (50 mg/kg) every other day. At the end of the study, the heart tissue was examined for pathological changes and the mRNA levels of Results: HFD-induced obesity led to increased Conclusion: In the findings, carvacrol was found to decrease the histopathological changes caused by HFD in heart tissue by suppressing the expression of genes involved in the apoptosis pathway.
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