Evidence map›Paper›PMID 40292252›Full record

ReviewOpen medicine (Warsaw, Poland)2025

Plant polyphenols, terpenes, and terpenoids in oral health.

Vida Arzani, Mohsen Soleimani, Tilman Fritsch, Ursula M Jacob, Vittorio Calabrese, Ahmad Arzani

Abstract readReview
In one paragraph

Review in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Targeting Oral Pathogens withAntibiotics (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vida ArzaniSchool of Dentistry, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-7272-1753
Mohsen SoleimaniDepartment of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Tilman FritschNAM Institute, Rochusgasse 13, 5020, Salzburg, Austria.
Ursula M JacobHealthcare AG, Zurich, CH, Switzerland.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124, Catania, Italy.
Ahmad ArzaniDepartment of Agronomy and Plant Breeding, College of Agriculture, Isfahan University of Technology, Isfahan, 8415683111, Iran.ORCID https://orcid.org/0000-0001-5297-6724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Herbal products are increasingly being used for their potential to promote oral health. Phytochemicals can act as scavengers of reactive or toxic chemicals, selective growth factors for beneficial oral bacteria, fermentation substrates for beneficial oral bacteria, and selective inhibitors of harmful oral microflora. Plant-derived secondary metabolites encompass a variety of natural products, including alkaloids, polyphenols (including flavonoids and tannins), terpenes, terpenoids, steroids, saponins, quinones, coumarins, glycosides, and carotenoids. Objectives: This review explores medicinal plant-based products for preventing and treating oral diseases, offering updated insights into the scientific basis for using herbs as active ingredients in oral health care. Hence, we focused on: (1) phenolic compounds, the most abundant and common phytochemicals and (2) terpenes and terpenoids, the most diverse and widely distributed group in the plant kingdom. Methods: Several databases were queried to acquire peer-reviewed studies focusing on the major phytochemical compositions - phenolic compounds, terpenes, and terpenoids - and their oral health benefits. Results: The review lists numerous medicinal herbs in various forms and applications for treating dental caries, gingivitis, and periodontitis. Conclusion: This review explores the evidence supporting the oral health-promoting effects of specific constituents in herbs with the potential for incorporation into pharmaceutical formulations.

Indexed as

antimicrobialbioactive compoundsdental cariesgingivitisperiodontitis

Identifiers

PMID40292252
PMCPMC12032991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.