Evidence map›Paper›PMID 40292088›Full record

ArticleTherapeutic advances in infectious disease

Predictive risk factors of treatment-refractory

Takahiko Saito, Yuya Aono, Masato Kono, Masaki Ishige, Takuma Sugiura, Misato Higasa, Fumiya Nihashi, Mineo Katsumata, Hideki Miwa, Yoshihiro Miki and 1 more

Abstract read
In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Critical reviews in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takahiko SaitoDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Yuya AonoDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo Ward, Hamamatsu, Shizuoka 430-8558, Japan.ORCID https://orcid.org/0000-0001-6132-2810
Masato KonoDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Masaki IshigeDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Takuma SugiuraDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Misato HigasaDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Fumiya NihashiDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Mineo KatsumataDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Hideki MiwaDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Yoshihiro MikiDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Dai HashimotoDepartment of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objectives: We aimed to identify the risk factors for refractory MAC-LD in response to initial GBT. Design: A retrospective single-center study was conducted involving consecutive patients with MAC-LD who were diagnosed between 2006 and 2024 and received initial GBT. Methods: Refractory MAC-LD was defined as sputum culture positivity at least 6 months after the initial GBT. Prognostic factors were identified using Cox proportional hazards analysis, and risk factors for refractory MAC-LD were examined using logistic regression analysis. Results: Of the 201 patients with definite MAC-LD, 35 (17.4%) had refractory MAC-LD. Patients with refractory MAC-LD had a significantly lower body mass index (BMI), more cavitary lesions on high-resolution computed tomography (HRCT), and higher mortality (log-rank test, Conclusion: Low BMI and cavitary lesions on HRCT are risk factors for refractory MAC-LD.

Indexed as

Mycobacterium avium complexnontuberculous mycobacteriaprognostic factorrefractory

Identifiers

PMID40292088
PMCPMC12033617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.