Evidence map›Paper›PMID 40291948›Full record

ReviewContact (Thousand Oaks (Ventura County, Calif.))

Mitochondria-Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function.

Jason C Casler, Matilde V Neto, Thomas Burgoyne, Laura L Lackner

Abstract readReview
In one paragraph

Review in Contact (Thousand Oaks (Ventura County, Calif.)). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason C CaslerDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID https://orcid.org/0000-0001-9742-9978
Matilde V NetoUCL Institute of Ophthalmology, University College London, London, UK.ORCID https://orcid.org/0000-0003-2267-6397
Thomas BurgoyneUCL Institute of Ophthalmology, University College London, London, UK.ORCID https://orcid.org/0000-0002-8428-720X
Laura L LacknerDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID https://orcid.org/0000-0003-0311-5199

Funding

Investigating the molecular mechanism of mitochondrial tetheringR01GM120303 · NIGMS · NORTHWESTERN UNIVERSITY · PI LACKNER, LAURA L · 2017 to 2025
$2.9M
The Functions of Mitochondrial Membrane Contact Sites in Space and TimeF32GM145160 · NIGMS · NORTHWESTERN UNIVERSITY · PI CASLER, JASON · 2022 to 2024
$213k
NIGMS NIH HHS F32 GM145160NIGMS NIH HHS R01 GM120303
6 · The paper itself

Abstract

Sites of close apposition between organelles, known as membrane contact sites (MCSs), are critical regulators of organelle function. Mitochondria form elaborate reticular networks that perform essential metabolic and signaling functions. Many mitochondrial functions are regulated by MCSs formed between mitochondria and other organelles. In this review, we aim to bring attention to an understudied, but physiologically important, MCS between mitochondria and the plasma membrane (PM). We first describe the molecular mechanism of mitochondria-PM tethering in budding yeast and discuss its role in regulating multiple biological processes, including mitochondrial dynamics and lipid metabolism. Next, we discuss the evidence for mitochondria-PM tethering in higher eukaryotes, with a specific emphasis on mitochondria-PM contacts in retinal cells, and speculate on their functions. Finally, we discuss unanswered questions to guide future research into the function of mitochondria-PM contact sites.

Indexed as

cell biologyelectron microscopyinterorganelle (inter-organelle)membrane contact sites (MCSs)‌mitochondrion (mitochondria)plasma membrane

Identifiers

PMID40291948
PMCPMC12033498

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.