Evidence map›Paper›PMID 40291934›Full record

ReviewJournal of medicine and life2025

Challenges of concurrent HIV infection in the course and management of Crohn's disease.

Lamyaa Mattar, Husna Irfan Thalib, Meral Alnuwaimi, Hanin Alsaadi, Huda Ahmed Allouji, Jena Alyafei, Layan Alshowiman, Nuran Alsobyani, Fatma El Sayed Hassan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lamyaa Mattar *Batterjee Medical College, Jeddah, Saudi Arabia.
Husna Irfan Thalib *Batterjee Medical College, Jeddah, Saudi Arabia.
Meral AlnuwaimiBatterjee Medical College, Jeddah, Saudi Arabia.
Hanin AlsaadiBatterjee Medical College, Jeddah, Saudi Arabia.
Huda Ahmed AlloujiBatterjee Medical College, Jeddah, Saudi Arabia.
Jena AlyafeiBatterjee Medical College, Jeddah, Saudi Arabia.
Layan AlshowimanBatterjee Medical College, Jeddah, Saudi Arabia.
Nuran AlsobyaniBatterjee Medical College, Jeddah, Saudi Arabia.
Fatma El Sayed HassanMedical Physiology Department, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crohn's disease (CD) is a chronic transmural bowel inflammation with a multifactorial etiology involving genetic predisposition and immune dysregulation in response to environmental triggers. In patients with human immunodeficiency virus (HIV), an already compromised immune system further complicates the progression and management of CD, creating unique therapeutic challenges. Probiotics have recently gained attention as a potential therapeutic option for CD, especially due to their role in modulating the gut microbiota. However, their effectiveness in patients with HIV, especially in enhancing and maintaining remissions, remains underexplored. This review aimed to examine how HIV infection influences the course of inflammatory bowel disease (IBD) and its impact on CD management strategies. A systematic literature search was conducted using Google Scholar, PubMed, Springer, and Web of Science to identify studies on patients with HIV and CD. HIV infection significantly alters the progression and management of CD due to its impact on the immune system. The immunosuppressed state of patients with HIV can complicate both the diagnosis and treatment of CD, often requiring adjustments in therapeutic approaches, necessitating a careful, tailored approach.

Indexed as

Crohn DiseaseHIV InfectionsDisease ProgressionGastrointestinal MicrobiomeHumansProbioticsAAD, Antibiotic-Associated DiarrheaAIDS, Acquired Immunodeficiency SyndromeAIEC, Adherent-Invasive Escherichia ColiAPC, Antigen-Presenting CellsART, Antiretroviral TherapyCARD15, Caspase Recruitment Domain–Containing Protein 15CARD9, Caspase Recruitment Domain–Containing Protein 9CAZymes, Carbohydrate-Active EnzymesCCL4, C-C Motif Chemokine Ligand 4CCR5, C-C Chemokine Receptor Type 5CD, Cluster Of DifferentiationCD, Crohn’s DiseaseCRC, Colorectal CancerCrohn’s diseaseCXCR4, C-X-C Chemokine Receptor Type 4DC, Dendritic CellsDC-SIGN, Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Non-IntegrinERS, Endoplasmic Reticulum StressFMT, Fecal Microbiota TransplantationFVT, Fecal Virome TransplantationGIT, Gastrointestinal Tractgut microbiotaHIVHIV, Human Immunodeficiency VirusIBD, Inflammatory Bowel DiseaseIFABP, Intestinal Fatty Acid–Binding ProteinILCs, Innate Lymphoid CellsIL, InterleukinMALT, Mucosa-Associated Lymphoid TissueMAMP, Microbe-Associated Molecular PatternNF-κB, Nuclear Factor Kappa BNK, Natural Killer CellsNOD2, Nucleotide-Binding Oligomerization Domain–Containing Protein 2NOS, Nitric Oxide SynthasepDC, Plasmacytoid Dendritic CellsPPAR-γ, Peroxisome Proliferator-Activated Receptor GammaprobioticsPRR, Pattern Recognition ReceptorsCD14, Soluble CD14SCFA, Short-Chain Fatty AcidsSLE, Systemic Lupus ErythematosusTGF-β, Transforming Growth Factor–βTh17, T Helper 17 CellsTLR, Toll-Like ReceptorTNF-α, Tumor Necrosis Factor–αUC, Ulcerative Colitis

Identifiers

PMID40291934
PMCPMC12022739

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.