ArticleWorld journal of gastrointestinal surgery2025
Magnetic resonance imaging bias field correction improves tumor prognostic evaluation after transcatheter arterial chemoembolization for liver cancer.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTranscatheter arterial chemoembolization (TACE) is a key treatment approach for advanced invasive liver cancer (infiltrative hepatocellular carcinoma). However, its therapeutic response can be difficult to evaluate accurately using conventional two-dimensional imaging criteria due to the tumor's diffuse and multifocal growth pattern. Volumetric imaging, especially enhanced tumor volume (ETV), offers a more comprehensive assessment. Nonetheless, bias field inhomogeneity in magnetic resonance imaging (MRI) poses challenges, potentially skewing volumetric measurements and undermining prognostic evaluation.
aimTo investigate whether MRI bias field correction enhances the accuracy of volumetric assessment of infiltrative hepatocellular carcinoma treated with TACE, and to analyze how this improved measurement impacts prognostic prediction.
methodsWe retrospectively collected data from 105 patients with invasive liver cancer who underwent TACE treatment at the Affiliated Hospital of Xuzhou Medical University from January 2020 to January 2024. The improved N4 bias field correction algorithm was applied to process MRI images, and the ETV before and after treatment was calculated. The ETV measurements before and after correction were compared, and their relationship with patient prognosis was analyzed. A Cox proportional hazards model was used to evaluate prognostic factors, with Martingale residual analysis determining the optimal cutoff value, followed by survival analysis.
resultsBias field correction significantly affected ETV measurements, with the corrected baseline ETV mean (505.235 cm³) being significantly lower than before correction (825.632 cm³,
conclusionVolume imaging based on MRI bias field correction can improve the accuracy of evaluating the efficacy of TACE treatment for invasive liver cancer. The corrected ETV and its reduction rate can serve as independent indicators for predicting patient prognosis, providing important reference for developing individualized treatment strategies.
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