ReviewJournal of oral biology and craniofacial research
Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis.
Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Introduction: Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene. Materials and methods: Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755 Results: A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32-5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87-4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I Conclusions: In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.
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