Evidence map›Paper›PMID 40291727›Full record

ArticlebioRxiv : the preprint server for biology2025

Isotope tracing-based metabolite identification for mass spectrometry metabolomics.

Deniz Secilmis, Arjana Begzati, Nina Grankvist, Irena Roci, Jeramie Watrous, Amit R Majithia, Gordon I Smith, Samuel Klein, Mohit Jain, Roland Nilsson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deniz SecilmisCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Arjana BegzatiUniversity of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, California 92093, United States.
Nina GrankvistCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Irena RociCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Jeramie WatrousUniversity of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, California 92093, United States.
Amit R MajithiaUniversity of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, California 92093, United States.
Gordon I SmithCenter for Human Nutrition, Washington University School of Medicine, St Louis, MO.
Samuel KleinCenter for Human Nutrition, Washington University School of Medicine, St Louis, MO.
Mohit JainUniversity of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, California 92093, United States.
Roland NilssonCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
The role of gut microbes and microbial derived metabolites in the development of type 2 diabetes in humansR01DK129840 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAJITHIA, AMIT · 2021 to 2025
$3.2M
Credentialing novel cardiovascular disease genes in women by sex-specific genomic investigation of insulin resistanceR01HL159760 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAJITHIA, AMIT · 2021 to 2024
$2.1M
NCATS NIH HHS UL1 TR000448NHLBI NIH HHS R01 HL159760NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK129840
6 · The paper itself

Abstract

Modern mass spectrometry-based metabolomics is a key technology for biomedicine, enabling discovery and quantification of a wide array of biomolecules critical for human physiology. Yet, only a fraction of human metabolites have been structurally determined, and the majority of features in typical metabolomics data remain unknown. To date, metabolite identification relies largely on comparing MS

Identifiers

PMID40291727
PMCPMC12027066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.