Evidence map›Paper›PMID 40291710›Full record

ArticlebioRxiv : the preprint server for biology2025

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.

Paige N Canova, Sarah Katzenell, Stacey Cerón, Audra J Charron, Jean M Pesola, Hyung Suk Oh, Donald M Coen, David M Knipe, David A Leib

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paige N CanovaDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Sarah KatzenellDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Stacey CerónDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Audra J CharronDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jean M PesolaDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Hyung Suk OhDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Donald M CoenDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David M KnipeDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David A LeibDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

Funding

VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
VIRAL & HOST FACTORS IN HERPETIC REACTIVATIONR01EY009083 · NEI · WASHINGTON UNIVERSITY · PI David A Leib · 1992 to 2026
$10.3M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
Does Antibody-Dependent Intracellular Neutralization Limit HSV-1 Reactivation?R21AI173941 · NIAID · DARTMOUTH COLLEGE · PI LEIB, DAVID A · 2023 to 2024
$451k
NEI NIH HHS R01 EY009083NIAID NIH HHS P01 AI098681NIAID NIH HHS R21 AI173941NIAID NIH HHS T32 AI007363
6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) establishes latent infections in sensory neurons, from which HSV sporadically reactivates due to external stress and other stimuli. Latency and reactivation are studied through

Identifiers

PMID40291710
PMCPMC12026746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.