Evidence map›Paper›PMID 40291697›Full record

ArticlebioRxiv : the preprint server for biology2025

An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis, independent of tissue-specific Microprocessor condensates.

Bing Yang, Brian Galletta, Rima Sakhawala, Nasser Rusan, Katherine McJunkin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bing YangNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, 50 South Drive, Bethesda, MD 20815.
Brian GallettaNational Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815.
Rima SakhawalaNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, 50 South Drive, Bethesda, MD 20815.
Nasser RusanNational Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815.
Katherine McJunkinNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, 50 South Drive, Bethesda, MD 20815.ORCID 0000-0001-9730-442X

Funding

Regulation of Centrosome Asymmetry in Stem CellsZIAHL006126 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI RUSAN, NASSER · 2011 to 2025
$19.4M
Biological functions and post-transcriptional regulation of microRNAsZIADK075147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MCJUNKIN, KATHERINE · 2018 to 2025
$14.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Intramural NIH HHS ZIA DK075147Intramural NIH HHS ZIA HL006126NIH HHS P40 OD010440
6 · The paper itself

Abstract

Precise control of miRNA biogenesis is of extreme importance, since mis-regulation of miRNAs underlies or exacerbates many disease states. The Microprocessor complex, composed of DROSHA and DGCR8, carries out the first cleavage step in canonical miRNA biogenesis. Despite recent advances in understanding the molecular mechanism of Microprocessor, the N-terminal region of DROSHA is less characterized due its high intrinsic disorder. Here we demonstrate that Microprocessor forms condensates with properties consistent with liquid-liquid phase separation (LLPS) in select tissues in

Identifiers

PMID40291697
PMCPMC12027344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.