Evidence map›Paper›PMID 40291686›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic and functional analysis of unproductive splicing using LeafCutter2.

Carlos F Buen Abad Najar, Ru Feng, Chao Dai, Benjamin Fair, Quinn Hauck, Jinghui Li, Xuewei Cao, Kushal K Dey, Philip De Jager, David Bennett and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carlos F Buen Abad NajarSection of Genetic Medicine, The University of Chicago, Chicago, IL.ORCID 0009-0000-4246-5154
Ru FengCenter for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY.
Chao DaiCommittee on Genomics, Genetics, and Systems Biology, The University of Chicago, Chicago, IL.
Benjamin FairCommittee on Genomics, Genetics, and Systems Biology, The University of Chicago, Chicago, IL.ORCID 0000-0001-6296-5703
Quinn HauckDepartment of Human Genetics, The University of Chicago, Chicago, IL.
Jinghui LiSection of Genetic Medicine, The University of Chicago, Chicago, IL.
Xuewei CaoCenter for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY.
Kushal K DeyComputational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.
Philip De JagerCenter for Translational & Computational Neuroimmunology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY.
David BennettRush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Alzheimer’s Disease Sequencing Project Functional Genomics Consortium
Xuanyao LiuSection of Genetic Medicine, The University of Chicago, Chicago, IL.
Gao WangCenter for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY.ORCID 0000-0001-9336-402X
Yang I LiSection of Genetic Medicine, The University of Chicago, Chicago, IL.ORCID 0000-0002-0736-251X

Funding

Alzheimer variants: Propagation of shared functional changes across cellular networksU01AG072572 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L, ST GEORGE-HYSLOP, PETER HENRY · 2021 to 2025
$8.5M
Novel methods to detect and interpret splicing quantitative trait loci - RenewalR01HG011067 · NHGRI · UNIVERSITY OF CHICAGO · PI Yang Li, JONATHAN P STALEY · 2020 to 2026
$4.2M
Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers diseaseR01AG076901 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gao Wang · 2023 to 2026
$2.4M
Computational genomics approaches to study mechanisms and function of mRNA splicingR35GM153249 · NIGMS · UNIVERSITY OF CHICAGO · PI Yang Li · 2024 to 2026
$1.2M
NHGRI NIH HHS R01 HG011067NIA NIH HHS R01 AG076901NIA NIH HHS U01 AG072572NIGMS NIH HHS R35 GM153249
6 · The paper itself

Abstract

Alternative splicing commonly generates unproductive mRNA transcripts that harbor premature termination codons

Identifiers

PMID40291686
PMCPMC12026817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.