Evidence map›Paper›PMID 40291677›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatial Analysis of Placentae During Congenital Cytomegalovirus Infection Reveals Distinct Cellular Profiles in Immune Cells and Trophoblasts.

Elise Sintim-Aboagye, Huy Quang Quach, Will Sherman, Sheila Farnan, Kamila Otrubova, Namisha Verma, Dawn Littlefield, Sohan Punia, Erica Johnson, Mark Blackstad and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elise Sintim-AboagyeDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Huy Quang QuachMayo Clinic Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Will ShermanDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Sheila FarnanDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Kamila OtrubovaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Namisha VermaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Dawn LittlefieldDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Sohan PuniaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Erica JohnsonDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Mark BlackstadDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, MN USA.
Mark R SchleissDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, MN USA.ORCID 0000-0002-2108-9433
Andrew P NorganDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Clive M GrayDivision of Immunology, Department of Biomedical Sciences, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa.
Elizabeth Ann L EnningaDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Rana ChakrabortyDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infectionR21HD103498 · NICHD · MAYO CLINIC ROCHESTER · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2020 to 2021
$390k
NICHD NIH HHS R21 HD103498
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is the most common cause of birth defects by an infectious agent. Approximately 10% of infants with congenital CMV (cCMV) infection are symptomatic. Infected infants can exhibit long-term effects such as sensorineural hearing and vision loss and neurodevelopmental delay. To date, the mechanisms by which cCMV infection results in symptomatic disease are incompletely understood. The placenta has been implicated as a main thoroughfare for vertical transmission, as both placental immune cells and trophoblasts can be infected by CMV. The goal of this study was to spatially investigate changes in genes and proteins from immune cells and trophoblasts during cCMV infection. Utilizing the NanoString GeoMx Digital Spatial Profiler, we noted that both immune cells and trophoblasts in CMV

Indexed as

congenitalcytomegalovirusimmune cellsplacentaproteomicstranscriptomicstrophoblasts

Identifiers

PMID40291677
PMCPMC12026742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.