Evidence map›Paper›PMID 40291673›Full record

ArticlebioRxiv : the preprint server for biology2025

TRPV1 Defends the Healthy Murine Cornea against

Orneika Flandrin, Yujia Yang, Sara Abboud, Naren G Kumar, Ananya Datta, Eric Jedel, Diana Bautista, David Evans, Suzanne Fleiszig

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Orneika FlandrinHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Yujia YangHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Sara AbboudHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Naren G KumarHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Ananya DattaHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Eric JedelHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.
Diana BautistaSchool of Cell and Molecular Biology, University of California, Berkeley, CA, USA.ORCID 0000-0002-6809-8951
David EvansHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.ORCID 0000-0002-6885-2053
Suzanne FleiszigHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA, USA.ORCID 0000-0001-6324-3462

Funding

Transient Receptor Potential Ion Channels and Corneal Defense Against Bacterial AdhesionR01EY030350 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 2019 to 2026
$3.0M
NEI NIH HHS R01 EY030350
6 · The paper itself

Abstract

Purpose: Previously we showed that transient receptor potential ion channels TRPA1 and TRPV1 selectively protect the cornea against bacterial adhesion, with TRPA1 countering the Gram-negative pathogen Methods: Healthy corneas of C57BL/6J wild-type (WT), TRPA1 (-/-) or TRPV1 (-/-) mice were challenged with Results: Corneas of TRPV1 (-/-) not TRPA1 (-/-) mice were found more susceptible to Conclusion: Healthy corneas utilize TRPV1 to protect against

Identifiers

PMID40291673
PMCPMC12027369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.