Evidence map›Paper›PMID 40291644›Full record

ArticlebioRxiv : the preprint server for biology2025

Adeno-associated viruses escort nanomaterials to specific cells and tissues.

Keisuke Nagao, Emmanuel Vargas Paniagua, Katherine Lei, Jacob L Beckham, Peyton Worthington, Marie Manthey, Matthew Ye, Florian Koehler, Ye Ji Kim, Elian Malkin and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Keisuke NagaoDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0009-0002-2296-1817
Emmanuel Vargas PaniaguaResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Katherine LeiDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Jacob L BeckhamResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Peyton WorthingtonDepartment of Mechanical Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Marie MantheyResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Matthew YeDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Florian KoehlerResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Ye Ji KimDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Elian MalkinResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Michika OnodaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Noah KentResearch Laboratory of Electronics, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Shota MichidaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Emily Crespin GuerraDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Robert J MacfarlaneDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.
Polina AnikeevaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0000-0001-6495-5197

Funding

Fusion of nanomagnetic and viral tools to interrogate brain-body circuitsDP1AT011991 · NCCIH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2021 to 2025
$5.3M
Wireless Magnetomechanical Neuromodulation of Targeted CircuitsR01NS115576 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2020 to 2020
$1.6M
NCCIH NIH HHS DP1 AT011991NINDS NIH HHS R01 NS115576
6 · The paper itself

Abstract

The delivery of nanotherapeutics to specific tissues relies on bespoke targeting strategies or invasive surgeries. Conversely, adeno-associated viruses (AAVs) can target specific tissues following intravenous injections. Here we show that cell-targeting properties of AAVs could be broadly conferred to nanomaterials. We develop a strategy to couple AAV capsids to nanoparticles that is invariant of viral serotype or nanomaterial chemistry and permits control over stoichiometry of the AAV-nanoparticle chimeras. The chimeras selectively escort nanoparticles into cell classes governed by AAV serotypes. When applied to magnetic nanoparticles, the AAV-nanoparticle chimeras enable magnetically localized gene delivery. In vivo, we show that leveraging the brain-targeting AAV serotype CAP-B10 achieves nanoparticle delivery to the parenchyma with ~10% efficiency (% injected dose/g

Identifiers

PMID40291644
PMCPMC12026743

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.