Evidence map›Paper›PMID 40291637›Full record

ArticlePlastic and reconstructive surgery. Global open2025

Sequential Applications of Adipose Tissue-derived Stem Cells Enhance Healing in Complex Wounds: Experimental Model.

Vitor P F Pagotto, Paula V Cacere, Silvana C Altran, Viviane A N C Dantas, Tatiane K Furuya, Deborah L S Santos, Maria José F Alves, Miyuki Uno, Cristina P Camargo, Rolf Gemperli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vitor P F PagottoFrom the Microsurgery and Plastic Surgery Laboratory (LIM04), Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Paula V CacereFrom the Microsurgery and Plastic Surgery Laboratory (LIM04), Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Silvana C AltranFrom the Microsurgery and Plastic Surgery Laboratory (LIM04), Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Viviane A N C DantasMultidisciplinary Research Center, School of Arts, Sciences and Humanities, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Tatiane K FuruyaCenter for Translational Research in Oncology (LIM24), Instituto do Câncer do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, São Paulo, Brazil.
Deborah L S SantosComissão de Residência Multiprofissional (COREMU), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, São Paulo, Brazil.
Maria José F AlvesCenter for Translational Research in Oncology (LIM24), Instituto do Câncer do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, São Paulo, Brazil.
Miyuki UnoCenter for Translational Research in Oncology (LIM24), Instituto do Câncer do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, São Paulo, Brazil.
Cristina P CamargoFrom the Microsurgery and Plastic Surgery Laboratory (LIM04), Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Rolf GemperliFrom the Microsurgery and Plastic Surgery Laboratory (LIM04), Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Complex wounds represent a challenge to global health, incurring significant healthcare costs and compromising patients' quality of life. Recently, research has investigated the potential of adipose tissue-derived stem cells (ASC) for therapeutic stem cells' immunomodulatory properties. This study aimed to evaluate the effect of sequential applications of ASC in an experimental model of a complex wound. Methods: Thirty male Wistar rats were subjected to a complex wound model of enterocutaneous fistula. After 4 weeks, the rats were divided into 3 groups: control, 2 applications of culture medium, and 2 applications of 1 × 10 Results: Animals treated with ASC showed a reduction in wound diameter of 68% compared with the control group ( Conclusions: This study demonstrated that the treatment with ASC improves the healing of enterocutaneous fistula wounds.

Identifiers

PMID40291637
PMCPMC12026421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.